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Volume 6, Issue 4 (Suppl)
Clin Pharmacol Biopharm, an open access journal
ISSN: 2167-065X
Page 84
Euro Biopharma & Ethnopharmacology 2017
November 09-11, 2017
&
6
th
International Conference and Exhibition on
November 09-11, 2017 Vienna, Austria
4
th
EUROPEAN BIOPHARMA CONGRESS
PHARMACOLOGY AND ETHNOPHARMACOLOGY
Joint Event
In vitro
antiplasmodial and antifungal activity of
morinda morindoides
(baker) milne-redh (rubiaceae),
an ivoirian traditional medecine plant
KIPRE Gueyraud Rolland
1
, BAGRE Issa
1
, SILUE Kigbafori Dieudonné
2
and
DJAMAN Allico Joseph
1,3
1
Université Félix Houphouët-Boigny, Ivory Coast
2
Laboratoire de Biologie Animale, Université Félix Houphouët-Boigny, Ivory Coast
3
Laboratoire de Biochimie, Institut Pasteur de Côte d’Ivoire, Ivory Coast
Introduction:
In Côte d'Ivoire and elsewhere in Africa, medicinal plants occupy a place of choice in the treatment of various
diseases. The survival and intensification of this practice today despite the prodigious development of modern medicine are
related to several factors, among which may be mentioned economic constraints and sociocultural factors. It is study that we
are interested in antimalarial and antifungal activity of
Morinda morindoides
, a plant used against fever and diarrhea in Côte
d'Ivoire.
Method:
Mmorindoides leaves were collected, air dried and made into a fine powder. Aqueous extracts (Aqe), ethanol (Eeth),
ethyl acetate (EAc) and acetate-water (EAc- H2O) were performed. Each extract was tested on
Plasmodium falciparum
and
Aspergillus fumigatus
.
Results:
IC50 values of different extracts are ranked in the following order: 6.1 (EAc) <17.8 (Eeth) <21.5 (Aqe) <46.5 (EAc-
H
2
O) for P. falciparum and 1.3 (EAc) <6.1 (Eeth) <12.47 (Aqe) < more than 300 (EAc-H2O) for A. fumigatus, the ethyl acetate
extract being the most active against both pathogens.
Conclusion:
These results show that M. morindoides leaves display significant antiplasmodial and antifungal activity, which
justifies its use in traditional medicine against malaria and mycoses.
Keywords :
Aspergillus fumigatus, Malaria, Plasmodium falciparum
Clin Pharmacol Biopharm 2017, 6:4(Suppl)
DOI: 10.4172/2167-065X-C1-026