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Volume 6, Issue 4 (Suppl)
Clin Pharmacol Biopharm, an open access journal
ISSN: 2167-065X
Page 80
Euro Biopharma & Ethnopharmacology 2017
November 09-11, 2017
&
6
th
International Conference and Exhibition on
November 09-11, 2017 Vienna, Austria
4
th
EUROPEAN BIOPHARMA CONGRESS
PHARMACOLOGY AND ETHNOPHARMACOLOGY
Joint Event
Nano multi arms biodegradable polymers for drug delivery
Hadi Salman Al-Lami
University of Basrah, Iraq
N
ovel triblock copolymers of poly(L-lactide)-poly(ethylene glycol)-sebacate-poly(ethylene glycol)-poly(L-lactide) were
synthesized by Ring-Opening Polymerization of different ratio of L-lactide using Diazabicyclo-[5.4.0]-undec-7-ene as
catalyst. These copolymers were fully characterized. They were used to prepare IPN’s which had a Nano fibre characteristic
as examined by Scanning Electron Microscopy. The swelling ratio, hydrolytic degradation and Insulin release studies were
performed at three different pH. It was found that the swelling ratio and the time needed to degrade fibre IPN’s increased with
increasing PEG chain length.
In vitro
insulin release showed that the longer the PLA chain length the slower the release rate.
Insulin release could be potentially controlled by PEG molecular weight, PLA content, pH, presence of Pluronic F-127 in the
IPN’s, crosslinking agent ratio, and the number of coated layers.
hadisalman54@yahoo.comClin Pharmacol Biopharm 2017, 6:4(Suppl)
DOI: 10.4172/2167-065X-C1-026