euro-biopharma-ethnopharmacology-2017-posters

Volume 6, Issue 4 (Suppl)

Clin Pharmacol Biopharm, an open access journal

ISSN: 2167-065X

Page 81

Euro Biopharma & Ethnopharmacology 2017

November 09-11, 2017

International Conference and Exhibition on

November 09-11, 2017 Vienna, Austria

EUROPEAN BIOPHARMA CONGRESS

PHARMACOLOGY AND ETHNOPHARMACOLOGY

Joint Event

Silymarin: As a multi-potential, novel and effective compound on diabetes and chemotherapy

Hassan Malekinejad

Urmia University of Medical Sciences, Iran

ilymarin (SMN) is a polyphenolic mixture of flavonolignans extracted from seeds of the milk thistle (Silybum marianum).

was found attribute to its capability in the reduction of NO and MDA levels and myeloperoxidase activity, suggesting

it’s not only antioxidant but also anti-nitrosative capacities. Traditionally, SMN has been used as a natural remedy for

digestive problems and in particular for diseases of the liver and the biliary tract, for menstrual disorders and varicose veins.

There are increasing data indicating beneficial effects of SMN on various disorders and diseases in different tissues. We in

our investigations during the last ten years found that SMN exerts remarkable protective and regulatory effects on drug

and xenobiotic biotransforming enzymes in experimentally-induced diabetic animals. At the same series of investigation we

explored that although both SMN and melatonin treatment was able to normalize the antioxidant status, while only SMN

administration could restore the β cells of Langerhans islets in diabetic rats. The anti-inflammatory property of SMN on

mono-iodoacetate- induced osteoarthritis and antinociceptive effects on acetic acid-induced reaction were also clarified. In

another study the SMN protective and preventive effects on doxorubicin-induced carbonyl stress, DNA damage, and its

capability in the alteration of c-myc gene expression were demonstrated. SMN beneficial effects on mycophenolate mofetil–

induced duodenal disorders

Clin Pharmacol Biopharm 2017, 6:4(Suppl)

DOI: 10.4172/2167-065X-C1-026