euro-biopharma-ethnopharmacology-2017-posters

Volume 6, Issue 4 (Suppl)

Clin Pharmacol Biopharm, an open access journal

ISSN: 2167-065X

Page 79

Euro Biopharma & Ethnopharmacology 2017

November 09-11, 2017

International Conference and Exhibition on

November 09-11, 2017 Vienna, Austria

EUROPEAN BIOPHARMA CONGRESS

PHARMACOLOGY AND ETHNOPHARMACOLOGY

Joint Event

The preventive effect of date palm (Phoenix dactylifera) seed and fruit hydro-alcoholic extracts on

carrageenan-induced inflammation in male rat’s hind paw

Farshid Asadi, Siavash Azarbani, Pooneh Kishani Farahani, Zahra Nazari

and

Mohsen Rezaei

Background & Objective:

The side effects of NSAIDS drugs, have caused increasing interest of scientists in herbal medicines

as alternative treatment. In this study, the effect of anti-inflammatory of seed and fruit of date palm hydro-alcoholic extracts,

due to having antioxidants, was studied.

Materials & Methods:

In this study, the extracts of date palm seed and fruit were prepared by maceration method in 70%

alcohol. Eighty male rats Wistar, divided into 10 groups of eight in each, 4 groups received different doses (100, 200, 400 and

600 mg/kg) of seed extract and 4 other groups different doses (100, 200, 400 and 600 mg/kg) of fruits extract of the palm, and

the positive control aspirin (300 mg/kg) and the negative control group saline (5 ml/kg) via injection intraperitoneally. Half an

hour later all animals received 100 µl of 1% carrageenan into the rat’s hind paw subcutaneous. The changes in rat’s paw edema

was measured by plethysmometer every hour for five hours.

Results:

The effect of the doses of date palm seed extract on edema were less than aspirin (P<0.05). But there was no significant

difference between the group that received 400 and 600 mg/kg date palm fruit extract when compared with aspirin group. The

dose 400 mg/kg of fruit extract showed the most anti-inflammatory effect and it was assigned as the best dose.

Conclusion:

It is likely that with further studies on different model of animals and on human model the palm fruit extract

could be used for pain treatment.

Clin Pharmacol Biopharm 2017, 6:4(Suppl)

DOI: 10.4172/2167-065X-C1-026