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Volume 6, Issue 4 (Suppl)
Clin Pharmacol Biopharm, an open access journal
ISSN: 2167-065X
Page 79
Euro Biopharma & Ethnopharmacology 2017
November 09-11, 2017
&
6
th
International Conference and Exhibition on
November 09-11, 2017 Vienna, Austria
4
th
EUROPEAN BIOPHARMA CONGRESS
PHARMACOLOGY AND ETHNOPHARMACOLOGY
Joint Event
The preventive effect of date palm (Phoenix dactylifera) seed and fruit hydro-alcoholic extracts on
carrageenan-induced inflammation in male rat’s hind paw
Farshid Asadi, Siavash Azarbani, Pooneh Kishani Farahani, Zahra Nazari
and
Mohsen Rezaei
Background & Objective:
The side effects of NSAIDS drugs, have caused increasing interest of scientists in herbal medicines
as alternative treatment. In this study, the effect of anti-inflammatory of seed and fruit of date palm hydro-alcoholic extracts,
due to having antioxidants, was studied.
Materials & Methods:
In this study, the extracts of date palm seed and fruit were prepared by maceration method in 70%
alcohol. Eighty male rats Wistar, divided into 10 groups of eight in each, 4 groups received different doses (100, 200, 400 and
600 mg/kg) of seed extract and 4 other groups different doses (100, 200, 400 and 600 mg/kg) of fruits extract of the palm, and
the positive control aspirin (300 mg/kg) and the negative control group saline (5 ml/kg) via injection intraperitoneally. Half an
hour later all animals received 100 µl of 1% carrageenan into the rat’s hind paw subcutaneous. The changes in rat’s paw edema
was measured by plethysmometer every hour for five hours.
Results:
The effect of the doses of date palm seed extract on edema were less than aspirin (P<0.05). But there was no significant
difference between the group that received 400 and 600 mg/kg date palm fruit extract when compared with aspirin group. The
dose 400 mg/kg of fruit extract showed the most anti-inflammatory effect and it was assigned as the best dose.
Conclusion:
It is likely that with further studies on different model of animals and on human model the palm fruit extract
could be used for pain treatment.
farshid_asadii@yahoo.comClin Pharmacol Biopharm 2017, 6:4(Suppl)
DOI: 10.4172/2167-065X-C1-026