21 / 25
Page 76
conferenceseries
.com
Volume 8
Journal of Biotechnology & Biomaterials
ISSN: 2155-952X
Pharma Biotech 2018
December 10-11, 2018
December 10-11, 2018 | Rome, Italy
23
rd
International Conference on
Pharmaceutical Biotechnology
Antidiabetic activity of aqueous extract of
Ruta montana L
. in streptozotocin-induced-diabetic rats
Mounira Merghem
and
Saliha Dahamna
University Ferhat Abbas Setif, Algeria
T
he aim of the present study was to evaluate antidiabetic activity of aqueous extract of
Ruta montana L.
in streptozotocin
induced diabetic rats. Diabetes mellitus was induced in rats by single intraperitoneal injection of streptozotocin (STZ,
50 mg/kg body weight). After STZ induction, the hyperglycemic rats were treated with aqueous extract orally at the dose
250 mg/kg body weight daily for 15 days. Insulin (6 U.I/kg) was used as reference drug. The control group was administered
with distilled water for the same duration. The fasting blood glucose levels were measured on every 5
th
day during the 15 day
treatment. The results showed that oral administration of aqueous extract at the dose of 250 mg/kg body weight decreased
blood sugar level in 5 to 15 days of treatment. The antidiabetic effect of aqueous extract was found to be comparable to that
the effect exerted by the reference drug, insulin at the dose of 6 U.I/kg. blood sugar level in rats treated by aqueous extract was
2.41±0.05, 1.32±0.36, 1.10±0.12 and 0.98±0.04 mg/dl at the 1, 5, 10 and 15 days respectively and in rats treated by insulin was
2.25±1.30, 1.04±0.33, 1.19±0.45, 0.48±0.15 mg/dl at the 1, 5, 10 and 15 days respectively.
mouniramerghem@yahoo.frJ Biotechnol Biomater 2018, Volume 8
DOI: 10.4172/2155-952X-C8-110