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Volume 8
Journal of Biotechnology & Biomaterials
ISSN: 2155-952X
Pharma Biotech 2018
December 10-11, 2018
December 10-11, 2018 | Rome, Italy
23
rd
International Conference on
Pharmaceutical Biotechnology
Synthesis, antibacterial activity and molecular docking studies of some new imine derivatives
Kastriot Ademi
and
Arben Haziri
University of Prishtina, Kosovo
T
he aim of this research work was to synthesize some new imine derivatives (Schiff bases) by using the reaction between
different heterocyclic amines and aromatic aldehydes. We have synthesized nine compounds (imine derivatives), five of
them are not known yet. These products are synthetized under reflection condition. The structure of the synthesized products
was determined based on IR and 1H NMR spectra. Compounds were screened for their antibacterial activity against gram
positive bacteria
Staphylococcus aureus
(clinical isolate),
Staphylococcus aureus
(food isolate),
Listeria monocytogenes
, and
against gram negative bacteria
Escherichia coli
. Compounds were found to be potent antimicrobial agent against gram positive
bacteria. All the compounds were subjected to molecular docking studies for the inhibition of the enzyme L-glutamine
D-fructose-6-phosphate amidotransferase [GlcN-6- P] (EC 2.6.1.16). The
in silico
molecular docking study results showed that
from nine synthesized compounds, seven of them shows minimum binding energy and have good affinity toward the active
pocket, thus, they may be considered as good inhibitor of GlcN-6-P synthase. From this research work we can conclude that
this synthesized compounds show antibacterial activities. The synthesized compounds can be used further by modifying their
structure with the aim to increase their biological activity.
kastriot.ademi@uni-pr.eduJ Biotechnol Biomater 2018, Volume 8
DOI: 10.4172/2155-952X-C8-110