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Euro Biotechnology 2016
November 07-09, 2016
Volume 6, Issue 7(Suppl) J Biotechnol Biomater
ISSN: 2155-952X JBTBM, an open access journal
conferenceseries .com
November 07-09, 2016 Alicante, Spain
12th Euro Biotechnology Congress
Elena Don et al., J Biotechnol Biomater 2016, 6:7(Suppl)
Released-active antibodies: Breakthrough concept of antibodies-based therapeutics
Elena Don, Elena Kardash, Alexandra Emelyanova, Nataliia Petrova and Oleg Epstein
Institute of General Pathology and Pathophysiology, Russia
Transformation of the antibodies (Abs) substances to final dosage form is a difficult task. The antibodies-based drugs have
some limitations while manufacturing and using like stability, toxicity, administration. I am pleased to acquaint you with
the drugs based on released-active Abs which have overcome the mentioned disadvantages. Phenomenon of released-activity
was explored and represented to the scientific community by Russian Professor Oleg Epstein. He suggested combining multiple
circles of consecutive decrease in the substance’s initial concentration and physical treatment up to the desired dilution with the
use as a substance such biotechnological product as Abs. This forward-looking manufacturing technique allows us to receive
reproducible product with unique features. Although the final dilution is too high to content any molecule of initial substance
these technologically treated product has an ability not to neutralize the targets but modify the interaction between the target
and corresponding molecule-regulator. High efficacy and lack of toxicity of release-active Abs-based drugs were confirmed
in plenty of preclinical studies and in top-quality clinical trials. Another astonishing effect of released-activity is observed
during conjoin use of the released-active substance with the initial one. Such application helps to increase the effectiveness
simultaneously with decreasing toxicity (against the initial substance in the same dose plus placebo) and could be used for
production of beneficial and advantaged biosimilars. Drugs based on released-active Abs is turning to be unique medicines
which combine the high efficacy and safety and several of them are already presented on the market of 16 countries.
Biography
Elena Don was graduated with a Master degree in Molecular and Cellular Biotechnology from Moscow State University of Fine Chemical Technologies, Russia.
Presently she is a PhD student focusing on pharmacology and immunoassays development at Institute of General Pathology and Pathophysiology, Russia. She
underwent a study course in immunoassay techniques at AB Biotechnology (Edinburgh, UK). She has published a number of manuscripts in reputed journals in
English and Russian and successfully participated in international conferences and congresses.