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Volume 4 Toxicology: Open Access
ISSN: 2476-2067 Toxicology Congress 2018
March 12-14, 2018
March 12-14, 2018 Singapore
14th World Congress on
Toxicology and Pharmacology
A study on exploring the toxicity of alcohol in the oral mucosa of alcoholics
Karthikeyan G
Saveetha Medical College and Hospital, India
Background: Oral cancer is the most common malignancy in nearly half of Indian population. The main causes of oral
carcinoma are tobacco, alcohol, poor diet and infective agents. These agents damage the chromosomes to form several
secondary nuclei known as micronuclei. This study identifies the occurrence of micronuclei and also evaluates the frequency
of micronuclei in stained smears of oral exfoliative cells from healthy subjects and alcoholic subjects.
Materials &Methods: A total number of 60 alcoholic subjects were referred to the Department of Anatomy, Saveetha Medical
College for micronucleus assay from the Department of Dentistry. Equal numbers of controls were included with normal
looking oral cavities.
Results: Out of 60 alcoholic subjects 43 showed presence of micronuclei and out of 60 control subjects, only 6 showed
micronuclei. With these observations it is found that alcohol is one of the factors predisposing to oral carcinoma.
Conclusion: It is evident from our present study, it is clear that in alcohol consumption, the buccal mucosa, which are at high
risk for development of oral cancer, show an increase in micro-nuclear frequencies.
Recent Publications
1. P K Sankaran, G Karthikeyan, M Kumaresan (2016) Morphometric study of renal artery and its variations in level of
origin. National Journal of Clinical Anatomy; 511-142.
2. P K Sankaran, MKumaresan, G Karthikeyan, Yuvaraj M (2015) Expression of Glial Fibrillary Acidic Protein (GFAP) in the
Trigeminal Ganglion of Male Wistar Rats. Indian Journal of Clinical Anatomy and Physiology; 2(3): 145-147.
Biography
Karthikeyan G is an Assistant Professor of Department of Anatomy at Saveetha Medical College & Hospital, India. He has upcoming research projects which are
granted by Indian Council of Medical Research.
Karthikeyan G, Toxicol Open Access 2018, Volume 4
DOI: 10.4172/2476-2067-C1-005