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Volume 4 Toxicology: Open Access
ISSN: 2476-2067 Toxicology Congress 2018
March 12-14, 2018
March 12-14, 2018 Singapore
14th World Congress on
Toxicology and Pharmacology
Brain free hemoglobin increase is different among anticoagulant classes
Sergey V Brodsky
The Ohio State University, USA
Background & Aim: Anticoagulant therapy is broadly used to prevent thromboembolic events. Intracranial hemorrhages
are serious complications of anticoagulation, especially with vitamin K inhibitors, including warfarin. Novel direct oral
anticoagulants (DOAC) reduce, but not completely eliminate the risk of intracranial hemorrhages. The aim of this study was
to investigate the severity of brain hemorrhages as measured by free hemoglobin in the brain parenchyma, among different
anticoagulant classes in rats.
Methods: Rats were treated with excessive doses (LD50) of different anticoagulant classes (vitamin K antagonists, including
brodifacoum and warfarin, heparin, direct thrombin inhibitor and factor Xa inhibitor). Free hemoglobin concentration was
measured in the brain.
Results: Vitamin K antagonists resulted in significant increase in free hemoglobin in the brain. Among DOAC, direct thrombin
inhibitor dabigatran also increased free hemoglobin in the brain, whereas treatment with factor Xa inhibitor rivaroxaban did
not have effect on free hemoglobin concentration.
Conclusion: Our data indicate that different anticoagulant class result in different accumulation of free hemoglobin in the
brain and it is more pronounced with vitamin K inhibitors.
Biography
Sergey V Brodsky is an Associate Professor of Department of Pathology, The Ohio State University Wexner Medical Center (OSUWMC), Columbus, OH. He has
published more than 25 papers in reputed journals and has been serving as an Editorial Board Member of American Journal of Physiology, American Journal of
Transplantation, ISRN Transplantation and Pharmacological Research.
Sergey V Brodsky, Toxicol Open Access 2018, Volume 4
DOI: 10.4172/2476-2067-C1-005