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Volume 4 Toxicology: Open Access
ISSN: 2476-2067 Toxicology Congress 2018
March 12-14, 2018
March 12-14, 2018 Singapore
14th World Congress on
Toxicology and Pharmacology
Synthetic bacteriophages as nanoparticles for intravenous administration of targeted gene therapy
for cancer
Keith Potent1, Armand Sinclair2
1Monash University, Australia
2Novother Cancer Research, New Zealand
We present a first in human case of a 50 year-old patient with end-stage metastatic ovarian cancer infused with a novel,
intravenously administered, synthetically engineered bacteriophage-based gene therapy (Metavec) for metastatic solid
malignancies. Compared to mammalian virus-based delivery vehicles, bacteriophage-based vectors bring many preferable
features for treatment in humans. Their genomes have been extensively sequenced and, with modern technologies, they are
relatively malleable allowing them to be extensively modified. Unlike mammalian viruses, bacteriophages are not natural
pathogens to humans yet their capsid can have equivocal cargo carrying capacity. To the authors’ best knowledge, no other
bacteriophage-based applications have succeeded with intravenous administration. This advance in nanotechnology and novel
approach could revolutionize medical care. The patient we discuss received a dose-escalating regime up to 1x1011 particles per
dose, three times a week for three weeks. The infusions were very well tolerated. Symptoms include nausea, low-grade fever,
and also discomfort in areas where larger tumors were present. Post-infusion investigations included serum biochemistry,
serum tumor markers, and computed tomography. The paradigm shift, results, and discussion will be presented.
Biography
Keith Potent is currently a PhD candidate in Translational Research at Monash University. After completing undergraduate degrees in Mathematics and Chemistry,
Dr Potent has completed his medical degree. He is a practicing doctor in Queensland.
Keith Potent et al., Toxicol Open Access 2018, Volume 4
DOI: 10.4172/2476-2067-C1-005