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Volume 4 Toxicology: Open Access
ISSN: 2476-2067 Toxicology Congress 2018
March 12-14, 2018
March 12-14, 2018 Singapore
14th World Congress on
Toxicology and Pharmacology
Toxicology of repeated iodine thyroid blocking on adult’s thyroid function and on the progeny’s brain
development
Lebsir Dalila1, Guemri Julien1, Manens Line1, Grison Stephane1, Kereselidze Dimitri 1, Phan Guillaume 1, Tack Karine1, Benderitter Marc1, Pech Annick2,
Lestaevel Philippe1 and Souidi Maamar1
1Institute for Radiological Protection and Nuclear Safety, France
2Central Pharmacy of Armed Forces, France
Statement of the Problem: Thyroid cancer (TC) is the major health
consequence of nuclear accident. To prevent TC incidence, a single dose of
potassium iodide (KI) is recommended to block thyroid radioiodine uptake. In
situation of prolonged exposure like Fukushima disaster, many doses of KI may
be necessary. Whereas single dose of KI transiently blocks thyroid function the
Wolff-Chaikoff effect, studies about the effects of repeated KI administration are
scarce. Thyroid hormones (THs) play an obligatory role in many fundamental
processes underlying brain development and maturation, the repeated KI
administration could modify (THs) level which may impact body functioning.
Purpose: To evaluate the impact of repeated administration of KI 1 mg/kg
in adult rat especially thyroid function and then in more sensitive model
the fetus with a particular focus on their central nervous system (CNS)
development.
Methodology & Theoretical Orientation: Adult male rats were subjected to either KI or saline solution over 8 days. Clinical
biochemistry, pituitary and thyroid hormones level, anti-thyroid antibodies level and thyroid genes expression were analyzed
30 days after stopping the treatment. The male progeny were subjected to KI indirectly through the treatment of their mothers
since (GD9) over 8 days and 30 days after the weaning, we evaluated the same parameters as for the adults, we also assessed
behavior and CNS genes expression.
Findings: We didn’t report any significant effect of repeated KI intake in adult. On the other hand we obtained a significant
decrease of TSH and FT4 in treated progeny, also the treatment significantly altered CNS genes expression and motor behavior
of progeny.
Conclusion & Significance: The data of adult may contribute to the ongoing developments of KI guidelines and marketing
authorization. Contrariwise toxic effect of repeated KI intake on immature brain requires more research.
References
1. Koukkou E G, N D Roupas, et al. (2017) Effect of excess iodine intake on thyroid on human health. Minerva Med; 108(2): 136-146.
2. Moog N K, S Entringer, et al. (2017) Influence of maternal thyroid hormones during gestation on fetal brain development.
Neuroscience; 342: 68-100.
3. Wu M, D Wu, et al. (2016) Relationship Between Iodine Concentration in Maternal Colostrum and Neurobehavioral
Development of Infants in Shanghai, China. J Child Neurol; 31(9): 1108-1113.
Biography
Lebsir Dalila is currently pursuing her PhD at the Institute of Radioprotection and Nuclear Safety and completed her Master’s degree in Experimental Pharmacology
at the University of Jijel, Algeria.
Lebsir Dalila et al., Toxicol Open Access 2018, Volume 4
DOI: 10.4172/2476-2067-C1-005