toxicology-congress-2017-posters-accepted-abstracts

6 / 28

Page 78
Notes:
conferenceseries.com
Volume 3, Issue 1 (Suppl) Toxicol Open Access
ISSN: 2476-2067 TYOA, an open access journal Toxicology Congress 2017
April 13-15, 2017
April 13-15, 2017 Dubai, UAE
8th World Congress on
Toxicology and Pharmacology
Cytotoxic effects of Androctonus australis hector venom on the isolated liver
Nadjia Bekkari and Fatima Laraba Djebari
University of Science and Technology Houari Boumediene, Algeria
Background: Androctonus australis hector (Aah) venom is well known by its high toxicity and when injected to animals, is able
to induce several symptoms starting by affecting cardiovascular dysfunctions, respiratory distress and tissue alterations such
as hepatic damages and acute inflammatory. These symptoms were related to the massive release of neurotransmitters after
neurotoxins binding on the ionic channels of peripheral nervous system.
Methods: In this study, we focus on the liver as probable direct target for Aah venom. Venom was administrated into isolated
liver. Tissue explant culture was used to quantify MPO and complement activities, the evaluation of oxidative status and
histological analysis were also carried.
Results: Results showed that the Aah venom induces several alterations and injuries. An unbalance of oxidative status is
expressed by the reduction of NO level and an increase of both MDA and GSH levels and the catalase activity. Inflammatory
cell hyperplasia was observed on the histological micrographies and associated with an increase of MPO and complement
system activities. Histological analysis also revealed apparition of necrosis areas.
Conclusion: These results indicate that Aah venom has cytotoxic effect on the isolated liver which is not related to
neurotransmitters or other systemic mediators released during scorpion envenoming. It seems that Aah venom contains some
bioactive components other than neurotoxins which could have direct target in this tissue.
Biography
Nadjia Bekkari has completed her PhD from USTHB University. She is member of research staff which work on venoms (snake and scorpion) under the direction
of Pr Laraba-Djebari Fatima. She has published 2 papers in reputed journals.
Nadjia Bekkari et al., Toxicol Open Access 2017, 3:1 (Suppl)