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Volume 3, Issue 1 (Suppl) Toxicol Open Access
ISSN: 2476-2067 TYOA, an open access journal Toxicology Congress 2017
April 13-15, 2017
April 13-15, 2017 Dubai, UAE
8th World Congress on
Toxicology and Pharmacology
Anti-neuroinflammation of brain-derived neurotrophic factor in microglia
Chingju Lin, Sheng-Wei Lai, Cheng-Fan Tsai and Dah-Yuu Lu
China Medical University, Taiwan
In the Central Nervous System (CNS), microglia plays a crucial role in innate immune processes. The hallmark of
neuroinflammation is considered to be microglial activation that leads to the production of excessive proinflammatory
molecules. Hence, inhibition effects on microglial over-activation are major strategy to counter balance neurodegenerative
progression. Brain-derived neurotrophic factor (BDNF) is one of the major neurotrophic factors to maintain development
and survival of neurons in the brain. However, how BDNF signalling participates in modulating neuroinflammatory responses
remains unknown. Recent studies have shown that BDNF is produced by astrocytes. Here, we reported experiments using
supplements with exogenous BDNF to examine the neuroprotective effects. BDNF causes decrease of cyclooxygenase-2 (COX-
2) as well as numerous proinflammatory cytokines. We found that BDNF resulted in increased expression of erythropoietin
(EPO) and sonic hedgehog (Shh) in microglia, this result causes further inhibition of inflammation effect. In addition, astrocyte
also acts through the endogenous mechanism to regulate microglia by increasing neuroprotective factor. The phosphorylated
adenosine monophosphate-activated protein kinase (AMPK)-α was mediating anti-neuroinflammatory responses inmicroglia.
In this study we provide the BDNF-EPO-Shh novel-signalling pathway involved in anti-inflammatory response via astrocyte-
microglia endogenous regulation.
Biography
Chingju Lin is an Associate Professor at the Department of Physiology at China Medical University, Taichung, Taiwan. In recent years, neuroinflammation
has been reported to be associated with the pathogenesis of neurodegeneration diseases. Her research interests focus on studying the relationship between
neuroinflammation and neurodegeneration. She is also interested in investigating Chinese herbal compounds or chemicals exerting anti-inflammation effects and
their potentials to be therapeutic drugs in treating neurodegeneration diseases.
Chingju Lin et al., Toxicol Open Access 2017, 3:1 (Suppl)