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Volume 3, Issue 1 (Suppl) Toxicol Open Access
ISSN: 2476-2067 TYOA, an open access journal Toxicology Congress 2017
April 13-15, 2017
April 13-15, 2017 Dubai, UAE
8th World Congress on
Toxicology and Pharmacology
Hazard identification in newly developed antimicrobials
Kejlová Kristina, Bendová Hana, Sosnovcová Jitka, Chrz Jan and Dvořáková Markéta
National Institute of Public Health, Czech Republic
Protection of consumer products such as food contact plastics, coatings, cosmetics and textiles against undesirable microbial
attack requires innovative agents with a wide spectrumof efficiency, long term stability and safety of use.These requirements
are often difficult to meet when using current biocides and antimicrobials. The aim of the currently performed research project
ALTERBIO is to identify and select innovative and efficient antimicrobial agents, based on silver nanoparticles and photoactive
phthalocyanine derivatives, able of covalent or ionic bond within a polymeric system and without undesirable effects on human
health and the environment. Within the project, the promising agents with proved efficient and stable antimicrobial effects
need to be subjected to a battery of toxicological tests to avoid local and systemic toxicity hazard. The battery of toxicological
test to identify local toxicity includes namely skin and eye irritation/corrosion, phototoxicity and skin penetration. The basic
systemic toxicity tests comprise acute toxicity, genotoxicity, skin sensitization and endocrine disruption. In compliance with
the current European legislation restricting the use of experimental animals the toxicological methods employed in the project
comprise exclusively in vitro procedures based on cellular and tissue models either of human origin or mimicking human
tissues. The presented poster summarizes the available methods and obtained results.
Biography
Kejlová Kristina graduated from the Charles University in Prague and received her PhD at the Palacký University in Olomouc. She works as the Head of Unit
for Alternative Toxicological Methods at the National Institute of Public Health in Prague, Czech Republic. She is an OECD and EURL-ECVAM expert for in vitro
methods. She has published more than 50 papers as author/co-author of reputed journals.
Kejlová Kristina et al., Toxicol Open Access 2017, 3:1 (Suppl)