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.com
Volume 9, Issue 5 (Suppl)
J Bioequiv Availab, an open access journal
ISSN: 0975-0851
Pharmacy & Biopharma 2017
August 31-September 01, 2017 Philadelphia, USA
August 31-September 01, 2017 Philadelphia, USA
3
rd
International Conference on
Biopharmaceutics and Biologic Drugs
&
5
th
International Pharmacy Conference
J Bioequiv Availab 2017, 9:5 (Suppl)
DOI: 10.4172/0975-0851-C1-031
Design and evaluation of press coated pulsatile release tablets of prednisolone
Upendra L Patel
Arihant School of Pharmacy and Bio-Research Institute, India
T
o formulate and evaluate a press coated pulsatile release tablets of prednisolone using an admixture of hydrophilic polymer,
i.e., low substituted hydroxy propyl cellulose (L-HPC) and hydrophobic polymer, i.e., ethyl cellulose (Ethocel 10 cps) to
achieve a pre-determined lag time for chronotherapy of rheumatoid arthritis. The press coated pulsatile tablets containing
prednisolone in the inner core were prepared by compression coating with L-HPC and Ethocel 10 cps as the outer layer in
different ratios. The effect of polymer ratio and weight gain of the outer layer on lag time of drug release was investigated using
32 full factorial design. The parameters determined were tablet hardness, friability, drug content, lag time,
in vitro
dissolution.
The release profile of the press coated tablet exhibited a distinct lag time before burst release of prednisolone. Lag time was
dependent on the ratio of L-HPC/Ethocel 10 cps and weight gain in outer shell. The lag time was from 1 to 10 hours and
could be modulated as it decreased as the amount of L-HPC in the outer layer increased. A surface plots are also presented to
graphically represent the effect of independent variables on the lag time. The validity of generated mathematical model was
tested by preparing checkpoint formulation. Formulation PCPT7 with L-HPC/Ethocel 10 cps (10:90) and weight gain 300
mg showing predetermined lag time of 5 hours prior to burst release of the drug from the press coated tablet was taken as the
optimized formulation.
upendra_patel01@rediffmail.com