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.com
Volume 9, Issue 5 (Suppl)
J Bioequiv Availab, an open access journal
ISSN: 0975-0851
Pharmacy & Biopharma 2017
August 31-September 01, 2017 Philadelphia, USA
August 31-September 01, 2017 Philadelphia, USA
3
rd
International Conference on
Biopharmaceutics and Biologic Drugs
&
5
th
International Pharmacy Conference
J Bioequiv Availab 2017, 9:5 (Suppl)
DOI: 10.4172/0975-0851-C1-031
Inhibition of spermatogenesis with the treatment of 50%methanolic extract of
Maytenus emarginata
leaves
inAlbino rats
Pratap Chand Mali
University of Rajasthan, India
S
ince population explosion threatens to human resources contraceptives used to check population. Due to drawbacks and
side effects of contraceptives, Scientists are still trying to search a new economic, reversibly effective and safe contraceptive
fromplants. Many plants have been explored for their fertility regulating properties around the world including India and China
in search to discover a male contraceptive agent because humans depend on plant products as sources of herbal therapeutic
agents without causing any side effects. The present study was planned to evaluate antifertility and reversible contraceptive
activity, therefore, 50% methanolic extracts of
Maytenus emarginata
leaves was prepared according WHO guidelines and
administered orally at the dose of 50, 100, 200 mg/kg/body wt/day for 60 days to develop an orally effective and reversible male
contraceptive. Results of the present study reveal a significant decline in the sperms motility and density of extract treated rats
as compared to control. The weight of seminal vesicles and testes was significant decreased in rats followed extract treatment
suggests anti-androgenic effects in rats. Proteins, ascorbic acid, cholesterol and fructose contents in testis and sex accessory
reproductive organs, as well as FSH, Testosterone hormones levels were decreased in rats treated with the extract. Histological
observation of testes showed degenerative changes in spermatogenesis in the lumen of seminiferous tubules, reduced sperm
number might be due to inhibition of spermatogenesis caused reduction of fertility in extract treated rats. It can be concluded
that oral treatment of 50% methanolic extract of
Maytenus emarginata
decreased fertility of male rats might be due to the
decreased level of proteins, fructose and hormones.
malipc_zool@yahoo.co.in