pharmacy-biopharma-2017-posters-accepted-abstracts

Page 68

conferenceseries

.com

Volume 9, Issue 5 (Suppl)

J Bioequiv Availab, an open access journal

ISSN: 0975-0851

Pharmacy & Biopharma 2017

August 31-September 01, 2017 Philadelphia, USA

August 31-September 01, 2017 Philadelphia, USA

International Conference on

Biopharmaceutics and Biologic Drugs

International Pharmacy Conference

J Bioequiv Availab 2017, 9:5 (Suppl)

DOI: 10.4172/0975-0851-C1-031

Formulation, design and evaluation of fast dissolving tablets of fexofenadine hydrochloride by lyophilization

technique

Rajendra Kotadiya

and

Bhavin Bhalani

Sigma Institute of Pharmacy, India

Indukaka Ipcowala College of Pharmacy, India

n the present study an attempt was made to formulate and evaluate fast dissolving tablets containing Fexofenadine HCl as a

model drug by Lyophilization technique. Fexofenadine HCl, is a non-sedating anti histamine used in the symptomatic relief

of allergic conditions including seasonal allergic rhinitis and urticaria with poor aqueous solubility. The study was aimed to

enhance the aqueous solubility and dissolution of drug by developing it into Lyophilized tablets. The Lyophilized tablets were

prepared by dispersing the drug in an aqueous solution of highly water-soluble polymers (gelatin, maltodextrose and acacia)

with glycine and mannitol. The mixture was poured into the pockets of blister packs and subjected to freezing followed by

Lyophilization. Prepared Lyophilized tablets were characterized by XRD, SEM, Mercury porosimetry, solubility, wetting, water

absorption ratio, drug content, dissolution and stability studies. Characterizations showed that tablets containing acacia had

fast disintegration and higher mechanical strength with improved solubility of Fexofenadine HCl. XRD study revealed that the

physical state of drug was unchanged with decreased crystalline structure. A good porous structure was observed for tablets as

per SEM. The total porosity, wetting time, water absorption ratio and drug content were found to be 23.27%, 7sec, 80.22 and

97.78%, respectively. Dissolution study showed almost 90% of drug released in 5 minutes. Comparison of selected batch was

made with the marketed formulation (MF) where our formulated batch showed 90% drug release in 30 min compared to 7 min

for MF. Moreover, tablets were found to be stable over a period of one month as well.