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conferenceseries
.com
Volume 9, Issue 5 (Suppl)
J Bioequiv Availab, an open access journal
ISSN: 0975-0851
Pharmacy & Biopharma 2017
August 31-September 01, 2017 Philadelphia, USA
August 31-September 01, 2017 Philadelphia, USA
3
rd
International Conference on
Biopharmaceutics and Biologic Drugs
&
5
th
International Pharmacy Conference
J Bioequiv Availab 2017, 9:5 (Suppl)
DOI: 10.4172/0975-0851-C1-031
Paradigm shift in classical drug research: Challenges to modern pharmaceutical sciences
Riddhi H Shukla, Rajeshri D Patel, Prakruti R Buch, Tejas P Sharma, Mihir K Raval
and
Navin R Sheth
Saurashtra University, India
M
any classical drugs are claimed to have blood sugar lowering properties that make them valuable for people with or at
high risk of type 2 diabetes. Vijaysar
(Pterocarpus marsupium)
and Gaumutra (Indian cow urine) both have been shown
antidiabetic property since primordial time and both shows synergistic effect in combination for hypoglycaemic activity. The
study was undertaken to investigate the hypoglycaemic and anti-diabetic effects of the combination of Vijaysar and Gaumutra
which is a classical preparation mentioned in Ayurveda named as Pramehari ark. Rats with Type 2 diabetes which is induced
by streptozotocin (STZ, 35mg/kg) given a high-fat diet for one month and compared with normal rats. Diabetic rats showed
raised level of body weight, triglyceride (TG), total cholesterol, HDL, LDL, and D-glucose concentration and other serum,
cardiac and hypertrophic parameters in comparison of normal rats. After treatment of different doses of drug the level of
parameters like TG, total cholesterol, HDL, LDL, and D-glucose concentration found to be decreased in standard as well as
in treatment groups. In addition treatment groups also found to be decreased in the level of serum markers, cardiac markers,
and hypertrophic parameters. The findings demonstrated that Pramehari ark prevented the pathological progression of type 2
diabetes in rats.
riddhi18190@gmail.com