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.com
Volume 9, Issue 5 (Suppl)
J Bioequiv Availab, an open access journal
ISSN: 0975-0851
Pharmacy & Biopharma 2017
August 31-September 01, 2017 Philadelphia, USA
August 31-September 01, 2017 Philadelphia, USA
3
rd
International Conference on
Biopharmaceutics and Biologic Drugs
&
5
th
International Pharmacy Conference
J Bioequiv Availab 2017, 9:5 (Suppl)
DOI: 10.4172/0975-0851-C1-031
Formulation and evaluation of liquid crystalline nanoparticles of artemether and lumefantrine for the
treatment of malaria
Vandana Chaudhary
1
, Shakir Hussain
2
and
Vijay Bhalla
1
1
SGT College of Pharmacy, India
2
Sidhi Vinayak College of Science, India
L
iquid crystalline nanoparticles of artemether and lumefantrine were prepared by using glyceryl monooleate, oleic acid,
poloxamer 407, ethanol and water. The optimization of liquid crystalline nanoparticles was achieved by response surface
methodology (BBD. 17 trials were prepared making use of artemether, lumefantrine and oleic acid in varying concentration
and GMO, poloxamer, ethanol and water were kept constant. Out of these F9 formulation was found best formulation. The
selection was made based on particle size and entrapment efficiency of artemether and lumefantrine. Optimized formulation
(OF1) contained particle size in the range of 193.5-194 nm (PDI 0.10) indicated that particle size was uniform. Entrapment
efficiency of artemether and lumefantrine were found 85% and 95.5%. Release study of artemether and lumefantrine revealed
that the drugs were released in a remarkably controlled manner up to 72 hrs. Physical and chemical stability study revealed that
the optimized formulation (OF9) was physically and chemically stable.
vandana13984@gmail.com