18 / 25
Page 65
conferenceseries
.com
Volume 9, Issue 5 (Suppl)
J Bioequiv Availab, an open access journal
ISSN: 0975-0851
Pharmacy & Biopharma 2017
August 31-September 01, 2017 Philadelphia, USA
August 31-September 01, 2017 Philadelphia, USA
3
rd
International Conference on
Biopharmaceutics and Biologic Drugs
&
5
th
International Pharmacy Conference
J Bioequiv Availab 2017, 9:5 (Suppl)
DOI: 10.4172/0975-0851-C1-031
Antidiabetic activity and phytoconstituents of
Anthocleista nobilis
Philip F Uzor, Joshua E Ahiabuike, Helen N Ani
and
Charles O Nnadi
University of Nigeria, Nigeria
T
he incidence of diabetes mellitus is rising at an alarming rate but the conventional drugs used for its management have
many limitations. Herbal medicines are known to be effective and safe for use in its management.
Anthocleista nobilis
G.
Don (
Gentianaceae
) is a plant used in the traditional management of diabetes. The present study was therefore designed to
establish and hence validate the use of the plant for the management of diabetes. It was also aimed at investigating quantitatively
the class of phytoconstituents present in the root and stem bark the plant. Phytochemical studies were done by the standard
procedures. The root and stem bark extracts of the plant were investigated for antidiabetic activity in alloxan-induced diabetic
rats. The animals were treated orally with 100, 200 and 400 mg/kg of both extracts for seven days. The fasting blood glucose
(FBG) of the animals was monitored for seven days. Abundance of terpenoids, alkaloids, flavonoids and tannins were observed
in both parts of the plant. Results also showed that the root and stem bark extracts significantly (p<0.001) reduced the FBG
of the diabetic animals in a dose related manner. The present study has validated the acclaimed traditional use of
A. nobilis
in
the management of diabetes. Terpenoids, alkaloids, flavonoids and tannins could be responsible for the antidiabetic activity of
the plant.
philip.uzor@unn.edu.ng