25 / 35
Page 89
Volume 08
Clinical Pharmacology & Biopharmaceutics
ISSN: 2167-065X
Pharmacology 2019
World Heart Congress 2019
August 19-20, 2019
JOINT EVENT
conferenceseries
.com
August 19-20, 2019 Vienna, Austria
&
7
th
World Heart Congress
24
th
World Congress on
Pharmacology
Prevention of atherosclerosis through dietary interventions
Mohammed Moghadasian
University of Manitoba and St. Boniface Hospital Research Centre, Canada
Introduction
: Atherosclerotic cardiovascular disease still remains as the top reasons for morbidity and mortality
worldwide. It was reported that cardiovascular disease was the cause of 13.7 million deaths in 2013; this number of
mortalityisexpectedtoreach24millionby2030.Onaverage,every40secondsonepersondiesofcardiovasculardisease
in USA. Many epidemiological studies highlighted a strong positive association between diets and cardiovascular
morbidity and mortality. We have reported that plant phytosterols significantly prevents atherogenesis in apo E-KO
mice. Human studies reported cholesterol-lowering efficacy for phytosterols. Therefore, it is recommended that 2
grams of phytosterols may reduce cardiovascular risk.
Objective
: to present anti-atherogenic effects of dietary agents.
Methodology
: LDL-r-KOmice were fed with a diet enriched with wild rice at 60% (w/w), or Kgengwe seed powder at
10% (w/w) for 20 weeks. A control group was fed with normal mouse chow. At baseline and during the experimental
course body weight, food intake, and plasma lipids were regularly measured. At the end of the study the hearts were
examined by light microscopic techniques to evaluate the development of atherosclerotic lesions in the aortic roots.
The aortae were used for examination of adhesion of monocytes to the endothelium. Final plasma samples were used
to estimate the levels of several common cyotokines.
Findings
: Treatment with wild rice or Kgengwe seed powder was associated with reductions in plasma cholesterol
levels. As compared to the control group, the treated groups had smaller atherosclerotic lesions in the aortic roots.
This anti-atherogenic effect of the dietary agents was associated with beneficial effects on inflammatory mechanisms
as assessed by monocyte adhesion to the endothelium or beneficial alterations in plasma cytokine profile.
Conclusions
: Both wild rice and Kgengwe seed powder may prevent atherogenesis through reductions in plasma
cholesterol levels and beneficial alteration in inflammatory biomarkers.
Clin Pharmacol Biopharm, Volume 08