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Volume 08
Clinical Pharmacology & Biopharmaceutics
ISSN: 2167-065X
Pharmacology 2019
World Heart Congress 2019
August 19-20, 2019
JOINT EVENT
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August 19-20, 2019 Vienna, Austria
&
7
th
World Heart Congress
24
th
World Congress on
Pharmacology
The effect of Olive leaf extract on the attenuation of ischemic brain damage in Rat
Abdolhamid Parsa, Mohammad Kamlinejad
and
Mohammad Babaeian*
Shahid Beheshti University of Medical Sciences, Iran
Introduction
: This study was designed to investigate whether the olive leaf extract (OLE) are effective in a
thromboembolic model of stroke in rat.
Methods
: Olive leaf aqueous extract 500mg/kg for 7 days were administered prior to stroke induction. Behavioral and
neurological scores, brain edema, infarct volume, the level of tumor necrosis factor-alpha (TNF-α), malondialdehyde
(MDA), catalase activity (CAT), and superoxide dismutase (SOD) changes were determined in the ipsilateral cortex
24 hr. after embolization.
Results
: Treated animals with (OLE) significantly showed brain infarction in a smaller size and less ipsilateral
hemisphere edema in comparison with the control group. Moreover, SOD and CAT values were significantly
decreased and the level of MDA was increased after stroke induction. The extract administration also improved
changes in biochemical markers of oxidative stress and TNF-α induced by stroke. The group receiving (OLE)
indicated less neurological and behavioral abnormalities in comparison to the control group.
Our findings proved the effectiveness of olive leaf aqueous extract in thromboembolic model of stroke which is most
probably due to the olive leaf extract antioxidant properties.
Clin Pharmacol Biopharm, Volume 08