31 / 35
Page 95
Volume 08
Clinical Pharmacology & Biopharmaceutics
ISSN: 2167-065X
Pharmacology 2019
World Heart Congress 2019
August 19-20, 2019
JOINT EVENT
conferenceseries
.com
August 19-20, 2019 Vienna, Austria
&
7
th
World Heart Congress
24
th
World Congress on
Pharmacology
Pharmacological correction of placental insufficiency with syndrome of growth retardation fetus
Klycheva O. I and Huraseva A. B
Kursk State Medical University, Russia
F
etoplacental Insufficiency (FPI) is an important problem of obstetrics. This pathological condition leads to the
development of fetal growth retardation syndrome (FGRS). Standard treatment regimens exist cannot be due to
a combination of individual etiological factors and pathogenetic mechanisms of development of this complication.
An important place in the treatment of occupied angioprotective drugs that improve blood flow, coagulation and
rheological properties of blood, tissue perfusion, to supply them with oxygen and nutrients.
Objectives
: the aim of the study was to compare the effectiveness of pharmacological agents commonly used
angioprotective pentoxifylline, diosmin and dipyridamole on the results of laboratory and instrumental methods of
research conducted after treatment.
Methods
: the retrospective and prospective survey of 120 pregnant women in terms of gestation from 28 to 36
weeks on a clinical basis of the Department of Obstetrics and gynecology KSMU on the basis of a burden «Regional
perinatal center» of the city of Kursk.
Results
: the study is developed and scientifically based option monotherapy placental insufficiency to fetal growth
retardation syndrome drug diosmin, aimed at improving the microcirculation in the system «mother-placenta-
fetus» for the purpose of having children with a higher weight and growth parameters. It is recommended to receive
a course for 1 month for 1 tablet (600 mg) per day in the morning on an empty stomach.
Conclusions
: When analyzing the results of instrumental research methods after pharmacological correction, an
equivalent improvement in hemodynamic parameters was revealed in both the uterine vessels and in the artery
of the umbilical cord, which is due to the action of the preparation diosmin, whereas pentoxifylline has a partial
positive effect on uterine and placental Blood flow and dipyridamole predominantly affects uterine blood flow.
Clin Pharmacol Biopharm, Volume 08