28 / 35
Page 92
Volume 08
Clinical Pharmacology & Biopharmaceutics
ISSN: 2167-065X
Pharmacology 2019
World Heart Congress 2019
August 19-20, 2019
JOINT EVENT
conferenceseries
.com
August 19-20, 2019 Vienna, Austria
&
7
th
World Heart Congress
24
th
World Congress on
Pharmacology
Aqueous extract of
Argania spinosa L
. fruits improves diabetes in streptozotocin-induced diabetic rats
Morad Hebi
1
, Farid Khallouki
1
, Rémy Burcelin
2
and
Mohamed Eddouks
1
*
1
Moulay Ismail University, Morocco
2
Rangueil Hospital, France
Introduction
: The argan tree (
Argania spinosa
L.) is an endemic species from south-western Morocco. Argan-based
preparations have been widely used in Moroccan traditional medicine for their biological properties including
diabetes especially argan oil. However, beside the effect of the oil a precise analysis of the impact of the pulp of A.
spinosa fruit on glucose and lipid control and metabolism has never been evaluated.
Objective
: The purpose of this study was to investigate the effect of a single dose and daily oral administration for
seven days of aqueous extract of pulp of
A. spinosa
fruit (A.E.P.F.A.S) in normal and streptozotocin (STZ)-induced
diabetic rats on blood glucose levels and plasma lipid profile.
Results
: Single oral administration of A.E.P.F.A.S reduced blood glucose levels 6 hours after administration in STZ
diabetic rats. Furthermore, the glycemic control was sustained for seven days during a chronic daily treatment.
The pretreatment with an A.E.P.F.A.S of diabetic rats significantly improves the glycemic control following an oral
glucose challenge when compared to the saline treated diabetic rats. Eventually, plasma cholesterol was reduced by
the treatment while antioxidant effects of A.E.P.F.A.S in severe diabetic state were observed.
Conclusion
: This study demonstrates that a treatment with A.E.P.F.A.S significantly improves plasma glucose and
cholesterol levels. In front of these promising results further investigations are needed to elucidate the mechanism(s)
of action of A.E.P.F.A.S and the active constituent(s) of the extract.
Keywords
:
Argania spinosa
; Antioxidant activity; Streptozotocin; Lipid profile; phytochemical screening.
Funding
: this work was supported by the CNRST under grant n° PPR/2015/35.
Clin Pharmacol Biopharm, Volume 08