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Volume 08
Clinical Pharmacology & Biopharmaceutics
ISSN: 2167-065X
Pharmacology 2019
World Heart Congress 2019
August 19-20, 2019
JOINT EVENT
conferenceseries
.com
August 19-20, 2019 Vienna, Austria
&
7
th
World Heart Congress
24
th
World Congress on
Pharmacology
Effects of pre- and postprandial aspirin on gastric bleeding based on clinical data and
in vitro
study
Guangjun Fan, Xueting Wang and Kang Jiang
The Second Hospital of Dalian Medical University, China
Statement of the Problem
: Aspirin is a common anti-inflammatory agent. Clinical pharmacists have found
an inconsistency in the timing of taking the medicine mentioned on the instructions of different brands of
aspirin(100mg). However, there are no relevant research on the medication time of aspirin has been previously
studied. This study aimed to investigate the effect of pre- or postprandial aspirin on GI bleeding, guide clinical
medication, reduce the risk of gastric hemorrhage and protect patients' reasonable rights.
Methodology & Theoretical Orientation
: The rational administration time of enteric-coated aspirin tablets was
explored through retrospective analysis of cases and
in vitro
drug dissolution tests. Data from 100 patients taking
enteric-coated aspirin tablets in the SecondHospital of DalianMedical University were retrospectively analyzed.They
included baseline information, medical history, brand of aspirin, time of taking medicine (fasting or postprandial),
gastric bleeding situation, and so on. Four groups were divided in the study. The Student t test and c2 test were used
for comparison among groups. The
in vitro
study based on high-performance liquid chromatography and basket
method conducted in different pH media (1.0–6.8) simulated changes in gastric pH after a meal, with a basket
rotation speed of 100 rpm. Findings: In this clinical cases, GI bleeding caused by aspirin had no relevance with
the medication time (before or after meals; P < 0.05). The
in vitro
dissolution experiment results suggested that no
obvious release of enteric-coated aspirin tablets occurred at pH 1.0-5.0, when it increased to 6.8, about 80% of the
drug was released. Conclusion & Significance: This study indicated that when the pH of stomach was below 5, aspirin
was not released in advance. Patients with an upset stomach should be advised to take aspirin before meals to prevent
aspirin release in advance and reduce the damage to the stomach.
Clin Pharmacol Biopharm, Volume 08