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Page 85
Volume 08
Clinical Pharmacology & Biopharmaceutics
ISSN: 2167-065X
Pharmacology 2019
World Heart Congress 2019
August 19-20, 2019
JOINT EVENT
conferenceseries
.com
August 19-20, 2019 Vienna, Austria
&
7
th
World Heart Congress
24
th
World Congress on
Pharmacology
Evaluation of the liver and renal function in patients of chronic heart failure based on the body mass
index: A retrospective study
Rohit Sane
and
Rahul Mandole
Madhavbaug Cardiac Care Clinics and Hospital, India
Statement of the Problem
: Chronic Heart Failure (CHF) is known to affect hepatic and renal function adversely, but
relevant Indian data is scarce. This study aimed to assess liver function tests (LFTs) and renal function tests (RFTs)
of CHF patients and their relation to BMI status.
Methodology & Theoretical Orientation
: The retrospective study considered data of patients who consulted
Madhavbaug clinics in Maharashtra, India between July-December 2018. Baseline LFTs and RFTs were analyzed
wholly and based on BMI status, viz. normal-BMI, overweight and obese.
Findings
: Of 147 patients, majority were males (74.15%) with mean age of 59.15+10.28 years. Based on BMI, three
patient sub-groups were made: (56 with normal BMI, 60 were overweight and 30 were obese). Mean SGOT and
SGPT were lower in obese group, but this was insignificant (p>0.05). Overall ALP was increased in all CHF patients
but was comparable in all three sub-groups (p>0.05). Mean direct bilirubin were above-normal in all sub-groups, but
mean total and indirect bilirubin were normal. Mean A/G ratio was normal in all sub-groups. Total serum protein
was below normal in all sub-groups, being lowest in overweight group, but these findings were insignificant (p>0.05).
RFTs, viz. BUN and serum creatinine, were normal and comparable in all sub-groups (p>0.05).
Conclusion & Significance
: Mild elevation in direct bilirubin and notable ALP elevations were seen in CHF patients
but their RFTs were normal. Mean LFTs and RFTs were comparable in patients with normal BMI, overweight or
obese patients, indicating lack of association between BMI and hepatic or renal function.
Clin Pharmacol Biopharm, Volume 08