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.com
Volume 8
Journal of Clinical & Experimental Pharmacology
Pharmacology and Medicinal Chemistry 2018
October 18-19, 2018
October 18-19, 2018 Dubai, UAE
International Conference on
18
th
International Conference on
&
Joint Meeting on
Pharmacology and Toxicology
Medicinal and Pharmaceutical Chemistry
In vivo
anti-inflammatory activity of ethanol extracts of the parijoto fruit (
Medinilla speciosa
Blume)
Nurmeilis Nurdjaman Pujianto, Puteri Amelia and Fitrahtunnisa
Syarif Hidayatullah State Islamic University Jakarta, Indonesia
P
arijoto
(Medinilla speciosa
Blume
)
is traditionally plant that used on diarrheal diseases, inflammation and cancer sores and
potentially as anti-hyperlipidemia and anti-bacterial that have been tested
in vivo
and
in vitro
. Based on research, parijoto
fruit contains secondary metabolites such as flavonoids, tannins, saponins and glycosides. The purpose of this study was to
determine the anti-inflammatory activity of the ethanol extract parijoto by using Carrageenan-Induced Paw Edema method.
Sprague Dawley rats were divided into five groups: Negative control (Na CMC 0.5% b/v), positive control (Diclofenac sodium
5.14 mg/kg BW), ethanol extract parijoto fruit in various doses of 100, 200 and 400 mg/kg body weight. The test substances
are given orally before induction with 0.2 mL carrageenan 1%. Measuring of the volume of rat's paw is conducted every hour
for five hours after carrageenan induction by using plethysmometer. The results showed that rats which were given ethanol
extract of 100, 200 and 400 mg/kg BW have significantly different percentage of edema compared to the negative control group
(p≤0.05). The percentage of edema inhibitions within the subjects group with doses of 100, 200 and 400 mg/kg BW are 74.58%,
72.88%, dan 50.85%, respectively. This result suggested that extract ethanol parijoto fruits are able to inhibit edema of rat’s paw
which is indicated that this extract has a potency to be developed as the anti-inflammatory agent.
Biography
Nurmeilis Nurdjaman Pujianto has completed her PhD from Faculty of Pharmacy University of Indonesia in 2016. She is a Lecturer in Pharmacology since 2005 at
Pharmacy Department Faculty of Medicine and Health Sciences Syarif Hidayatullah State Islamic University (UIN) Jakarta, Indonesia. She is currently (since 2016)
the Head of Pharmacy Department. She has published several paper in both international and national journal also presentation as oral presenter in international
conference.
nurmeilis@uinjkt.ac.idNurmeilis Nurdjaman Pujianto et al., Clin Exp Pharmacol 2018, Volume 8
DOI: 10.4172/2161-1459-C3-034