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Volume 8 Journal of Clinical & Experimental Pharmacology Pharmacology and Medicinal Chemistry 2018
October 18-19, 2018
October 18-19, 2018 Dubai, UAE
International Conference on
18th International Conference on
&
Joint Meeting on
Pharmacology and Toxicology
Medicinal and Pharmaceutical Chemistry
Potential nutritional and in vitro inhibitory effects on α-glucosidase of sea hare (Dolabella auricularia)
Azrifitria Amiruddin, Benny Manullang and Sri Purwaningsih
Syarif Hidayatullah State Islamic University Jakarta, Indonesia
Dolabella auricularia, also known as sea hare, is a marine gastropod that it found in the waters of Indo – Pacific. The aims of
this research were to explore the potential of nutritional content of the species and in vitro anti-diabetic activity of sea hare
extract. The composition of fatty acid was measured by gas chromatography, amino acids were measured by high performance
liquid chromatography and mineral was measured by atomic absorption spectrophotometer. In vitro anti-diabetic activity of
the sea hare extracts was evaluated by measuring their inhibitory effect on alpha-glucosidase level. The sea hare contained
nine essential amino acids and six non-essential amino acids. Total saturated fatty acids was at 5.33% (g /100g), MUFA at
2.11% (g/ 100g), PUFA at 4.1% (g/100g). Calcium was at 68100 mg/kg, potassium at 10000 mg/kg, sodium at 8200 mg/kg, and
carbohydrate at 1.52%. Sea hare ethyl acetate extract has in vitro anti-diabetic activity better than methanolic extract. The ethyl
acetate extracts inhibited alpha-glocosidase activity in vitro, in a concentration dependent manner (IC50=25.76 mg/mL). The
present study confirms that sea hare had a rich source of nutritional and their inhibitory effects on alpha-glucosidase.
Biography
Azrifitria has completed her PhD at the Indonesia University School of Medicine. She is the Head of Pharmacy Department at Syarif Hidayatullah State slamic
University Jakarta, Indonesia. She has published several papers in reputed journals and get some course at pharmacy field at Tokushima Bunry Japan.
Azrifitria Amiruddin et al., Clin Exp Pharmacol 2018, Volume 8
DOI: 10.4172/2161-1459-C3-034