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Volume 8 Journal of Clinical & Experimental Pharmacology Pharmacology and Medicinal Chemistry 2018
October 18-19, 2018
October 18-19, 2018 Dubai, UAE
International Conference on
18th International Conference on
&
Joint Meeting on
Pharmacology and Toxicology
Medicinal and Pharmaceutical Chemistry
Novel bufadienolide glycoside and a homoisoflavonoid from Rhodocodon campanulatus (Asparagaceae)
Alaa Alqahtani1,2 Moses K1,2, Dulcie A Mulholland1,2 and Wolfgang Wetschnig3
1University of Surrey, UK
2Umm-al-Qura University, Saudi Arabia
3University of Graz, Austria
Rhodocodon campanulatus is a member of the bulbous Urgineeae tribe of
the Scilloideae subfamily of the expanded Asparagaceae family (formerly
Hyacinthaceae). Plants of the Urgineeae tribe are used as traditional remedies
for the treatment of several ailments, such as infections, rheumatism,
inflammation and disorders associated with the central nervous system.
The Urgineeae tribe is distributed from South Africa to the Mediterranean,
Saudi Arabia, India and Myanmar. The chemical constituents of plants of the
Rhodocodon genus are not documented and hence the plant was investigated for chemo-taxonomical reasons. In this study we
report the isolation of a novel bufadienolide glycoside and a known homo-isoflavonoid from the ethanol extract of the bulbs
of Rhodocodon campanulatus. The major compounds were novel bufadienolide glycoside, 1, 3β-(O-β-D-glucopyranoside)-
14β-hydroxybufa-20,22-dienolid-19-al, and the known homo isoflavonoid, 2, 5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)
chroman-4-one, previously isolated from the South African Scilla kraussi. The structures of 1 and (2, 2a-b) (figure 1) were
determined by the analysis of their NMR and MS spectra. The absolute configuration at C-3 for 2 was determined in this study
as S on the basis of its electronic circular dichroism study. A positive Cotton effect at 290 was in agreement to those reported
for homo isoflavonoid with H-3 in β position. Compound 1 was screened against NCI60 cancer cell lines and did not show any
significant growth inhibition. Compound 2-2a-b was tested for anti-angiogenic inhibition ability. Compound 2b was found to
be effective against the angiogenesis of human retinal micro vascular endothelial cells (HRECs) with GI50 values of 128 μM.
Recent Publications
1. Schwikkard Sianne, Alqahtani Alaa, Knirsch Walter, Wertschnig Wolfgang, Jaksevicius Andrius, Opara Elizabeth, Langat
Moses K and Mulholland Dulcie (2017) Phytochemical investigations of three Rhodocodon (Hyacinthaceae sensu APG II)
species. J. Nat. Prod ; 80: 30-37.
References
1. Goel A, Ram V J, (2009) Tetrahedron; 65: 7865-7913.
2. Koorbanally N A, Koorbanally C, Harilal A, Mulholland D A, Crouch N R (2004) Phytochem; 65: 3069-3073.
3. Crouch N R, Mulholland D A (1999) Phytochem; 51: 943-946.
4. Adinolfi M, Barone G, Corsaro M M, Mangoni L (1988) Tetrahedron; 44, 15: 4981-4888.
Biography
Alaa Alqahtani is an Assistant Professor in Pharmaceutical Chemistry Department at Umm Al- Qura University. She has completed her Graduation from Umm Al-
Qura Universityand Master’s in Chemistry with Biological Chemistry from University of Hull, UK. She completed her PhD from Surrey University, UK in the field of
Natural Products Chemistry (Pharmaceutical Chemistry). Her research focuses on the discovery of novel drugs from traditional medicinal plants, marines and their
determination of their absolute stereo structures using electronic circular dichroism. Her areas of expertise includes, isolation, identification and quantification of
compounds from natural sources, synthesis of bioactive molecules and examine the possible biological activities of these compounds.
Alaa Alqahtani ., Clin Exp Pharmacol 2018, Volume 8
DOI: 10.4172/2161-1459-C3-034
Figure 1:The structure of compounds isolated
from Rhodocodon campanulatus.