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Volume 8 Journal of Clinical & Experimental Pharmacology Pharmacology and Medicinal Chemistry 2018
October 18-19, 2018
October 18-19, 2018 Dubai, UAE
International Conference on
18th International Conference on
&
Joint Meeting on
Pharmacology and Toxicology
Medicinal and Pharmaceutical Chemistry
Astudy of CYP2C19*2, *3 and *7 in different Sudanese ethnic groups and their response toOmeprazole
based triple therapy in Khartoum, Sudan 2016-2017
Safinaz Ibrahim Khalil
University of Medical Sciences and Technology, Sudan
Background: Pharmaco-genetics is an important branch of pharmacology and should be applied to assist the clinical usage of
medicines which has a strong relation with enzyme activity of certain genes and alleles known through the literature. CYP2C19
is known to affect the activity of omeprazole and this will result in different responses to treatment. The commonest alleles
through the literature are CYP2C19*2 and CYP2C19*3 which vary according to different ethnicity of different populations.
Methodology: A purposeful convenient sampling; in which patients with peptic ulcer disease and treated with omeprazole
were reviewed and the PCR is used to differentiate the CYP2C19 different alleles in patients presenting from February 2016 to
January 2017.
Results: In the present study we investigated the distribution of three common gene variants affecting the omeprazole treatment
of peptic ulcer disease and H. pylori eradication namely to CYP2C19*2, *3 and *7. The CYP2C19*2 mutation was found among
all seven ethnic groups of Sudan, Arabs mostly 17 (139) followed by Darfurians 9 (139), Beja 6 (139) and Nilotes 6 (139), Nuba
5 (139) then Nubians 3 (139) and Fulani 1 (139), p=0.048 which is significant. Regarding CYP2C19*3 mutation of this allele
is found in certain ethnic groups Arabs 6 (139), Nubians 6 (139) and Nuba 2 (139), p=0.043 significant. There is no mutation
found among different Sudanese ethnic groups in CYP2C19*7. Arabs are normal homozygotes 6 (139) and Darfurians 1 (139).
Nuba 1 (139) was found to be heterozygotes in this allele p=0.038 significant. Treatment of H. pylori with omeprazole-based
triple therapy was used in 110 (139) and no significant correlation found with the different ethnic groups of Sudan.
Conclusion: These data indicate that Sudanese seven ethnic groups showed activity of CYP2C19*2, CYP2C19*3 were they
took omeprazole based triple treatment and some of them showed activity to CYP2C19*7.
Biography
Safinaz Ibrahim Khalil has her expertise in evaluation and passion in improving the health and wellbeing. Her open and contextual evaluation model based on
responsive constructivists creates new pathways for improving healthcare. She has built this model after years of experience in research, evaluation, teaching and
administration both in hospital and education institutions.
Safinaz Ibrahim Khalil, Clin Exp Pharmacol 2018, Volume 8
DOI: 10.4172/2161-1459-C3-034