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Volume 8
Journal of Biotechnology & Biomaterials
ISSN: 2155-952X
Euro Biotechnology 2018
October 11-12, 2018
October 11-12, 2018 | Moscow, Russia
21
st
European
Biotechnology Congress
conferenceseries
.com
Page 54
Active metabolites of the marine strain
Streptomyces sundarbansensis
with highest and
selective antibacterial activity against methicillin-resistant
Staphylococcus aureus
(MRSA)
Mouloud Kecha, Ibtissem Djinni, Andrea Defant
and
Ines Mancini
University of Bejaia, Algeria
F
our polyketides were isolated from the algal-derived endophytic actinomycete
Streptomyces sundarbansensis,
which represents the lacking member in the recently reported series of phaeochromycins A–E. We also proposed
a method based on the comparison of experimental IR spectra with the DFT ones calculated in order to establish
the tautomeric forms for these metabolites. The results indicated a γ-pyrone structure for these compounds, in
analogy to the related polyketides mutactin and SEK34. Due to this study, it is possible to suggest that also the
known phaeochromycins were isolated mainly in this tautomeric form, differently by the structures reported until
now. Evaluation of IC50 values on the pure and structurally defined metabolites as inhibitors of Gram positive and
Gram negative bacteria, from where the new compound showed the highest and selective antibacterial activity
against MRSA.
kmksetif@yahoo.frJ Biotechnol Biomater 2018, Volume 8
DOI: 10.4172/2155-952X-C5-101