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Volume 8
Journal of Biotechnology & Biomaterials
ISSN: 2155-952X
Euro Biotechnology 2018
October 11-12, 2018
October 11-12, 2018 | Moscow, Russia
21
st
European
Biotechnology Congress
conferenceseries
.com
Page 52
Multiple inhibitory activities of
Urgenia
species
M N Shiva Kameshwari
Bangalore University, India
T
he genus
Urginea
belongs to family Asparagaceae is found growing in India, Africa, and Mediterranean regions of
the world. It is one of the medicinally important genera showing multiple activities to cure various deadly diseases.
In the present study anti-inflammatory, anti-diabetic, anti-Alzheimer’s, anti-cancer, anti-oxidant and anti-osteoporosis
activity of
Urginea
species have been discussed. Methanol extract of
U. wightii
has shown inhibition against raw 264.7
cell lines in lipoxygenase, inhibition assay and exhibited the IC value of 200.7 µg/ml with quercetin as standard. Anti-
oxidant activity was determined by nitric oxide free radical scavenging assay where curcuminoids was used as standard.
U. indica
and
U. wightii
showed significant anti-oxidant activity with IC value of 174.1 µg/ml and 371.9 µg/ml respectively.
Anti-diabetic activity was detected using alpha amylase inhibition assay with acarbose as standard. Both
U. indica
and
U. wightii
have shown significant results with IC value of 253.7 µg/ml and 202.2 µg/ml respectively. Anti-Alzheimer
activity was analysed using acetylcholinesterase assay with neostigmine as standard.
U. indica
showed IC value 121 µg/
ml against standard 0.04 µg/ml. Cell proliferative activity of the extraction on UMR 106 lines against osteoporosis, has
revealed. IC
50
value of 185.9µg/ml in
U. indica
and 69.75µg/ml in
U. wightii
. Anti-cancer activity was determined against
cell line MCF-7 using MTT assay. Both the species have showed significant results inhibiting cell growth in MCF-7 cell
line and exhibited IC
50
value of 325.9µg/ml in
U. indica
and 424.3µg/ml in
U. wightii
. These results show
Urginea
species
have a magical potential to heal deadly diseases. Further work is in progress.
mn.shivakameshwari@gmail.comJ Biotechnol Biomater 2018, Volume 8
DOI: 10.4172/2155-952X-C5-101