euro-biotechnology-2016_posters-accepted-abstracts

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Euro Biotechnology 2016

November 07-09, 2016

Volume 6, Issue 7(Suppl)

J Biotechnol Biomater

ISSN: 2155-952X JBTBM, an open access journal

conferenceseries

.com

November 07-09, 2016 Alicante, Spain

Euro Biotechnology Congress

Woo-Young Jeon et al., J Biotechnol Biomater 2016, 6:7(Suppl)

Samsoeum water extract attenuates allergic airway inflammation via modulation of Th1/Th2

cytokines and decrease of iNOS expression in asthmatic mice

Woo-Young Jeon

, Mee-Young Lee

, In-Sik Shin

and Hyeun-Kyoo Shin

Korea Institute of Oriental Medicine, South Korea

Chonnam National University, South Korea

Background & Aim:

Samsoeum has long been used in Korea and other Asian countries as a traditional medicine to treat

various diseases. In this study, we investigated the antiasthma effect of the herbal medicine Samsoeum water extract (SSEW)

using an ovalbumin (OVA)-induced asthma mouse model.

Methods:

BALB/cmicewere sensitizedby an intraperitoneal injectionofOVAand subsequently challengedwithnebulizedOVA.

We investigated the number of inflammatory cells, the production of Th1/Th2 cytokines and chemokine in bronchoalveolar

lavage fluid (BALF), histological changes in lung tissue, the infiltration of inflammatory cells and hyperplasia of goblet cells

in lung tissue, the levels of immunoglobulinE (IgE) in BALF and plasma and the expression of inducible nitric oxide synthase

(iNOS) in lung tissue.

Results:

Our results indicated that SSEW decreased the accumulation of inflammatory cells (particularly, eosinophil and

neutrophil) and regulated the balance in the production of Th1/Th2 cytokines and chemokine in BALF. Moreover, SSEW

suppressed the level of IgE in BALF and plasma and inhibited the infiltration of inflammatory cells, hyperplasia of goblet cells

and the expression of iNOS in lung tissue.

Conclusions:

These findings suggest that, because of its anti-inflammatory and antiasthma properties, SSEWmay be useful in

reducing airway inflammation in the treatment of asthma.