euro-biotechnology-2016_posters-accepted-abstracts

11 / 22

Notes:
Page 65
Euro Biotechnology 2016
November 07-09, 2016
Volume 6, Issue 7(Suppl) J Biotechnol Biomater
ISSN: 2155-952X JBTBM, an open access journal
conferenceseries .com
November 07-09, 2016 Alicante, Spain
12th Euro Biotechnology Congress
Meeyoung Lee, J Biotechnol Biomater 2016, 6:7(Suppl)
Safety assessment of Guibi-tang: Subchronic toxicity study in Crl:CD SD rats
Meeyoung Lee
Korea Institute of Oriental Medicine, South Korea
Guibi-tang (Kihi-To in Japanese and Qui-Pi-Tang in Chinese) is a multiherbal traditional Korean medicinal formula used
for treatment of amnesia, fatigue, poor memory or forgetfulness, anemia, insomnia and necrosis. The aim of the present
study was to investigate potential safety, if any, of subchronic administration of Guibi-tang aqueous extract (GBT) in laboratory
animals. For this study, 0, 1000, 2000 and 5000 mg/kg/day of GBT was administered to Crl:CD Sprague Dawley rats (10/sex/
group) for 13 weeks via oral gavage. Administration of the GBT did not result in any mortality, body weight, food consumption,
hematology, serum biochemistry, clinical or ophthalmological signs or changes in urinalysis, gross findings or organ weight.
However, histopathology revealed forestomach hyperplasia and duodenum mucosal hyperplasia in rats of both sexes at the
highest dose of GBT, 5000 mg/kg/day. Therefore, the no-observed-adverse-effect level in rats was established for GBT at 2000
mg/kg/day under the conditions of this study.
Biography
Meeyoung Lee has completed his Master’s and Doctor’s degree from the College of Veterinary Medicine, Chungnam National University. He is the Researcher
working in K-herb Research Center of Korea Institute of Oriental Medicine. She has published more than 10 papers in reputed journals.