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Analytica 2016
September 28-30, 2016
Volume 7, Issue 5(Suppl) J Anal Bioanal Tech 2016
ISSN: 2155-9872 JABT, an open access journal
conferenceseries .com
September 28-30, 2016 Orlando, USA
7th International Conference and Exhibition on
Analytical & Bioanalytical Techniques
Junqing Zhang, J Anal Bioanal Tech 2016, 7:5(Suppl)
Differential systemic exposure to galangin after oral and intravenous administration to rats
Junqing Zhang
Hainan Medical University School of Pharmacy, China
Galangin (3,5,7-trihydroxyflavone) is present in high concentrations in Alpinia officinarum Hance. It shows multifaceted
in vitro and in vivo biological activities. The number and position of hydroxyl groups in this molecule play an important
role in these biological activities. In order to clarify the exposure of galangin after oral and intravenous administration to
rats, two LC-MS/MS methods were developed and validated and successfully applied to analyze the parent drug molecules
and aglycones liberated from plasma samples via β-glucuronidase hydrolysis. Our major findings were as follows: The
routes of administration showed significant influences on the systemic exposure of galangin and its metabolites; galangin
was preferentially glucuronidated after p.o. dosing but sulfated after i.v. medication; kaempferol conjugates were detected
demonstrating that oxidation reaction occurred; however, both glucuronidation and sulfation were more efficient and; oral
bioavailability of free parent galangin was very low. The results showed that systemic exposure to galangin and its metabolites
was different in rat plasma between oral and intravenous administration. Further research is needed to characterize the
structures of galangin conjugates and to evaluate the biological activities of these metabolites.
Biography
Junqing Zhang has completed his MD at 2013 from Nanjing University of Chinese Medicine. She is the Dean of the College of Pharmacy, Hainan Medical University.
She has published more than 25 papers in reputed journals and has been serving as an Editorial Board Member of repute.