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Analytica 2016
September 28-30, 2016
Volume 7, Issue 5(Suppl) J Anal Bioanal Tech 2016
ISSN: 2155-9872 JABT, an open access journal
conferenceseries .com
September 28-30, 2016 Orlando, USA
7th International Conference and Exhibition on
Analytical & Bioanalytical Techniques
Ghazale Daneshvar Tarigh et al., J Anal Bioanal Tech 2016, 7:5(Suppl)
Direct enantioenrichment of DL-mandelic acid by in situ immobilization of a general resolving agent
on the magnetic multi wall carbon nanotube
Ghazale Daneshvar Tarigh and Farzaneh Shemirani
University of Tehran, Iran
L-threonine (L-thr) as a general chiral selector anchored on the surface of magnetic multi wall carbon nanotube (MMWCNT)
was prepared using an in situ electrostatic adsorption and studied as a new magnetically chiral selector for the separation
of chiral DL-mandelic acid (DL-MA) as a model sample. By varying the pH, DL-MA was adsorbed on the surface of magnetic
chiral selector through hydrogen bonds. It was recognized that MMWCNT with chiral ligands on its surface simultaneously
possessed both magnetic property and direct chiral recognition ability. The successful immobilization of L-thr onto the
surface of MMWCNT was confirmed by infrared spectra (FT-IR), X-ray diffraction patterns (XRD) and transmission electon
microscopy (TEM). The FT-IR and mass spectra of supernatant and elution solutions also confirmed the immobilization
of L-thr onto the surface of MMWCNT. The analysis results of specific rotation, HPLC and ultraviolet-visible spectroscopy
revealed that the L-thr-MMWCNT showed stronger complexation of (+)-enantiomer than (-)-enantiomer. The functional
magnetic nanotubes were easily separated from the racemic solution using an external magnetic field which demonstrated its
feasibility of recycling the adsorbent. All processes including in situ immobilization, enantioseparation (enantioenrichment)
and magnetic separation were done by single process in a short time (only 10 min).
Biography
Ghazale Daneshvar Tarigh has completed her PhD in Analytical Chemistry from University of Tehran, Iran in 2015, BSc in Pure Chemistry at the University of
Zanjan in 2003 and MSc under the direction of Prof. Yadollah Yamini at TMU and Prof. Ali Jabbari at KNTU in 2009. Her field of interest is the development of new
extraction technologies with an emphasis on miniaturized sample preparation methods and separation techniques.