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Volume10, Issue 12 (Suppl) J Proteomics Bioinform, an open access journal
ISSN: 0974-276X
Page 61
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World Biomarkers & Pharma Biotech 2017
December 07-09, 2017
December 07-09, 2017 | Madrid, Spain
&
20th International Conference on
PHARMACEUTICAL BIOTECHNOLOGY
9th WORLD BIOMARKERS CONGRESS
JOINT EVENT ON
Antioxidant and Anticancer Activities of Sorbus rufopilosa extract in Human Colon adenocarcinoma
HT29 Cells
You Na Oh, Soojung Jin, Hyun Ju Kwon, and Byung Woo Kim
Dong-Eui University, South Korea
Sorbus rufopilosa, a tsema rowan, is a species of the small ornamental trees in the genus Sorbus and the family Rosaceae
found in East Asia. The antioxidant and anticancer effects of S. rufopilosa remain unclear. The objective of this study is to
evaluate the antioxidant and anticancer effects of ethanol extract of S. rufopilosa (EESR) and the molecular mechanism of its
anticancer activity in human colon carcinoma HT29 cells. EESR showed significant antioxidant activity and inhibitory effect
on HT29 cell growth in a dose-dependent manner. EESR induced cell cycle arrest at G2/M phase in a dose-dependent manner
by modulating the expression of cyclin B, cyclin-dependent kinase 1 (CDK1), and CDK inhibitor p21. EESR-induced apoptosis
was associated with the upregulation of p53, a death receptor Fas, a pro-apoptotic protein Bax and the activation of caspase 3, 8,
and 9, resulting in the degradation of poly ADP ribose polymerase (PARP). These results suggest that EESR efficiently inhibits
proliferation of HT29 by inducing both cell cycle arrest and apoptosis, and may be a possible candidate for the anticancer drug
development.
Recent Publications:
1. Andreas G (2003) Introduction to apoptosis. ApoReview 2-26.
2. Evan GI, Vousden KH (2001) Proliferation, cell cycle and apoptosis in cancer. Nature 411:342-348.
3. Fulda S (2015) Targeting apoptosis for anticancer therapy. Semin. Cancer Biol. 31:84-88.
4. Fulda S, Debatin KM (2006) Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene
25:4798-4811.
5. Udensi UK, Tchounwou PB (2016) Oxidative stress in prostate hyperplasia and carcinogenesis. J. Exp. Clin. Cancer
Res. 35:139.
Biography
You Na Oh has completed her Master in Microbiology from Dong-Eui University, Busan, Republic of Korea. She is currently working as a researcher at Blue-Bio
Industry Regional Innovation Center, Dong-Eui University. Her research is focused on Bioactive Natural
You Na Oh et al., J Proteomics Bioinform 2017, 10:12(Suppl)
DOI: 10.4172/0974-276X-C1-110