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Volume 4 Toxicology: Open Access
ISSN: 2476-2067 Toxicology Congress 2018
March 12-14, 2018
March 12-14, 2018 Singapore
14th World Congress on
Toxicology and Pharmacology
Effect of honey on rate of healing of socket after tooth extraction in rabbits
Deependra Prasad Sarraf, Jaisani Mehul Rajesh, Shrestha Ashish and Rauniar Gajendra Prasad
B.P. Koirala Institute of Health Sciences, Nepal
Statement of the Problem: Honey is the worlds’ oldest known wound dressing. Its wound healing properties is not fully
established till today. Concerns about antibiotic resistance and a renewed interest in natural remedies, have prompted
resurgence in the antimicrobial and wound healing properties of honey. Evidence from animal studies and some trials has
suggested that honey may accelerate wound healing in burns, infected wounds and open wounds. None of these reports have
documented the effect of honey on healing of socket after tooth extraction. Therefore, the present experimental study was
planned to evaluate the efficacy of honey on the healing of socket after tooth extraction in rabbits.
Methodology &Theoretical Orientation: An experimental study was conducted in six New Zealand white rabbits. Extraction
of first premolar tooth on both sides of lower jaw was done under anesthesia produced by ketamine and xylazine followed by
application of honey on one socket (test group) and normal saline (control group) in the opposite socket. The intervention was
continued for two more days. On 7th day, biopsy was taken from the extraction site and histo-pathological examination was
done. Student’s t-test was used for comparison between the groups and differences were considered to be statistically significant
at p value less than 0.05.
Findings: There was a significant difference between control group and test group in terms of fibroblast proliferation (p=0.0019)
and bony trabeculae formation (p=0.0003). Inflammatory cells were also observed in both groups and it was not significant
(p=1.0). Overlying epithelium was hyperplastic in both the groups.
Conclusion & Significance: The study showed that local application of honey promoted the rapid healing process particularly
by increasing fibroblast proliferation and bony trabeculae.
Recent Publications
1. DP Sarraf, GP Rauniar, H Sangraula (2013) Effect of Ocimum gratissimum in rodents. Health Renaissance; 11(3): 198-204.
2. A Misra, DP Sarraf, GP Rauniar (2013) Prescribing Pattern of Antimicrobials in the In-Patients Department of Obstetrics
and Gynaecology at A Tertiary Care Teaching Hospital at Nepal. International Journal of Pharmaceutical & Biological
Archives; 4(5): 893–898.
Biography
Deependra Prasad Sarraf has his expertise in in vivo studies of natural herbs and medicinal foods. He is also involved in undergraduate and postgraduate medical
students’ teaching, thesis guidance and mentoring.
Deependra Prasad Sarraf et al., Toxicol Open Access 2018, Volume 4
DOI: 10.4172/2476-2067-C1-006