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Volume 4
Toxicology: Open Access
ISSN: 2476-2067
Toxicology Congress 2018
March 12-14, 2018
March 12-14, 2018 Singapore
14
th
World Congress on
Toxicology and Pharmacology
Nanofiber sheets using small intestinal sub-mucosa for skin wound healing
Minju Kim
Ajou University, South Korea
C
urrently, various wound healing agents are being developed. The patch-type therapeutic agent for skin wound healing
has almost no side effects and the drug is delivered to the body at a constant rate, it is a new concept drug treatment that
can be applied directly. Most of the conventional patch type therapeutic agents have limitations in that the drug is not well
controlled due to the structure of the film, so that the drug is not smoothly absorbed into the skin and the secondary infection
is a concern due to poor ventilation and sterilization. In this work, nanofiber sheets (NS) as patch-type therapeutic agent
using small intestinal sub-mucosa (SIS) prepared by electro-spinning. Nano-fibers have a large surface area and high porosity.
The large surface area not only sufficiently constitutes the wet state but also has a three-dimensional structure similar to the
extracellular matrix structure (ECM), so that drug release is facilitated at the wound site and effective for skin regeneration.
Also, SIS, a natural material, has excellent biocompatibility and is an ECM with signaling bio-active molecules, cytokines and
many other factors, so it has the advantage of controlling cell function. In this experiment, the nanofiber morphology of the
SIS-NS was evaluated by SEM. The absorbability of SIS-NS was evaluated by contact angle test. The cytotoxicity of SIS-NS was
evaluated and the wound healing effect was confirmed
in vitro
. Also, the skin wound healing effects of SIS-NS was evaluated by
in vivo
experiments such as incision and staining for 3 weeks. In conclusion, these results indicate that SIS-NS is effective for
skin wound healing and SIS-NS can be applied as a therapeutic agent for various types of skin wound healing effects.
Biography
Minju Kim is currently studying at Regenerative Medicine Laboratory in Ajou University. Her main research interests are drug delivery system.
goroki42@ajou.ac.krMinju Kim, Toxicol Open Access 2018, Volume 4
DOI: 10.4172/2476-2067-C1-006