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conferenceseries
.com
Volume 9, Issue 5 (Suppl)
J Bioequiv Availab, an open access journal
ISSN: 0975-0851
Pharmacy & Biopharma 2017
August 31-September 01, 2017 Philadelphia, USA
August 31-September 01, 2017 Philadelphia, USA
3
rd
International Conference on
Biopharmaceutics and Biologic Drugs
&
5
th
International Pharmacy Conference
J Bioequiv Availab 2017, 9:5 (Suppl)
DOI: 10.4172/0975-0851-C1-031
Design, synthesis and biological evaluation of novel antiproliferative agents
Dinesh Kumar
Guru Nanak Dev University, India
4
,6-diarylpyrimidones as constrained chalcone analogues have been synthesised in the present study. The synthesised
compounds were evaluated against a panel of human cancer cell lines. Striking selectivity was displayed by the compounds
against MiaPaCa-2 (Pancreatic) cell lines while PC-3 (prostate) and A-549 (lung) cell lines were almost resistant to the exposure
of the test compounds. Compound SK – 25 exhibited remarkable cytotoxicity against MiaPaca-2 cell line with an IC50 value of
1.95 μM and was found to induce apoptosis evidenced through phase contrast microscopy, DAPI staining and mitochondrial
membrane potential loss. The cell phase distribution studies indicated that the apoptotic population increased from 1.79% in
control sample to 30.33% in sample treated with 20 μM compound SK-25.
dinesh_arora_81@yahoo.co.in