11 / 25
Page 58
conferenceseries
.com
Volume 9, Issue 5 (Suppl)
J Bioequiv Availab, an open access journal
ISSN: 0975-0851
Pharmacy & Biopharma 2017
August 31-September 01, 2017 Philadelphia, USA
August 31-September 01, 2017 Philadelphia, USA
3
rd
International Conference on
Biopharmaceutics and Biologic Drugs
&
5
th
International Pharmacy Conference
J Bioequiv Availab 2017, 9:5 (Suppl)
DOI: 10.4172/0975-0851-C1-031
Effects of microbubble size on ultrasound-induced transdermal delivery of high-molecular-weight drugs
Chih-Hung Wang, Taiwan
Ai-Ho Liao, Taiwan
T
ransdermal drug delivery can be assisted and enhanced by sonophoresis with ultrasound (US)-aided microbubbles (MBs).
The conventional transdermal delivery of a wide range of high-molecular-weight drugs is limited by the outermost layer
of the epidermis, with the stratum corneum representing the main barrier to penetration across the skin. The present study
determined the different effects of various sizes ofMBs that underwent US exposure to enhance the transdermal delivery of high-
molecular-weight drugs. The effects of US-mediated MBs of different sizes (1.4, 2.1, and 3.5 μm) and ascorbyl tetraisopalmitate
(VC-IP, a cosmetic ingredient for skin lightening) on enhancing skin transdermal delivery were demonstrated both
in vitro
and
in vivo
. The results indicated that the US power intensities of a 3 W/cm2 penetration depth in the US group combined with
3.5-μm MBs and penetrating VC-IP (U+3.5) were 34% and 14% higher than those in the US group combined with 1.4-μm
MBs and penetrating VC-IP (U+1.4) and US combined with 2.1-μmMBs and penetrating VC-IP (U+2.1), respectively, for the
agarose phantoms; the corresponding increases for pigskin were 37% and 19%. In terms of the skin permeation of VC-IP, the
VC-IP concentrations in the U+3.5 group were 23% and 10% higher than those in the U+1.4 and U+2.1 groups, respectively.
The whitening effect (luminosity index) of mouse skin in the U+3.5 group significantly increased by 28% after 1 week and
34% after 2 weeks, while it tended to stabilize after 3 weeks (45%), in C57BL/6J mice over a 4-week experimental period. In
conclusion, to the best of our knowledge, this is the first study to demonstrate that US combined with MBs of different sizes
can produce different degrees of skin permeability to enhance the delivery of high-molecular-weight drugs like VC-IP for skin
brightness without damaging the skin.
chw@ms3.hinet.net