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.com
Volume 9, Issue 5 (Suppl)
J Bioequiv Availab, an open access journal
ISSN: 0975-0851
Pharmacy & Biopharma 2017
August 31-September 01, 2017 Philadelphia, USA
August 31-September 01, 2017 Philadelphia, USA
3
rd
International Conference on
Biopharmaceutics and Biologic Drugs
&
5
th
International Pharmacy Conference
J Bioequiv Availab 2017, 9:5 (Suppl)
DOI: 10.4172/0975-0851-C1-031
Vancomycin loaded super paramagneticMnFe
2
O
4
nanoparticles coatedwithPEGylated chitosan to enhance
antibacterial activity
Akbar Esmaeili
and
Sepideh Ghobadian Pour
Islamic Azad University, Iran
Background & Aims:
Increasing prevalence of antibiotic-resistant and failed-treatment make more investigations to deal
with these problems. Hence new therapeutic approaches for effective treatment are necessary. Ferrite super paramagnetic
nanoparticles have potentially antibacterial activity.
Methods:
In this study we prepared MnFe2O4 super paramagnetic nanoparticles as core by precipitation method and used
chitosan crosslinked by glutaraldehyde as shell, then modified with PEG to increase stability of particles against RES.
Results:
Chitosan coating not only improves the properties of ferrite nanoparticles but also has antibacterial activity. FT-IR
confirmed this surface modification XRD and SEM were developed to demonstrate particle size and characteristics of crystal
structure of these nanoparticles. Final particle size was reported approximately 25 nm. Magnetic properties of nanoparticles
were evaluated by VSM. Actual drug loading and releasing were examined by (UV-Vis) spectroscopy method.
Conclusions:
We employed liquid broth dilution method to assessment antibacterial activity of nanoparticles against
microorganisms. Significant antibacterial effect against gram negative bacteria was developed.
akbaresmaeili@yahoo.com