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.com
Volume 9, Issue 5 (Suppl)
J Bioequiv Availab, an open access journal
ISSN: 0975-0851
Pharmacy & Biopharma 2017
August 31-September 01, 2017 Philadelphia, USA
August 31-September 01, 2017 Philadelphia, USA
3
rd
International Conference on
Biopharmaceutics and Biologic Drugs
&
5
th
International Pharmacy Conference
J Bioequiv Availab 2017, 9:5 (Suppl)
DOI: 10.4172/0975-0851-C1-031
Quercetin ameliorates the hepato-renal toxicity induced by
Echis coloratus
snake venom in rats
Abdulrahman K Al Asmari, Rajamohamed Abbasmanthiri, Nasreddien Mohammed Abdo Osman, Sara Abdulrahman Al Asmari
and
Faiz Saeed
Prince Sultan Military Medical City, Saudi Arabia
T
he application of new drugs derived from plant resources were being investigated and explored by scientists since long
ago, for snakebite treatment, as an alternative to anti-venom therapy, that has several limitations. Flavonoids, the naturally
produced antioxidants, are abundantly available in plants, and are largely consumed in daily diet, recently. The aim of this
study is to investigate and evaluate the potential effects of the flavonoid (quercetin) on envenoming of albino rats by sub-lethal
venom (3.84 mg/kg, i.p.) doses of
Echis coloratus (Ec)
viper crude venom. Quercetin (30 µM/kg, i.p.) doses were administered
to evaluate their beneficial effects on the induced venom hepato-renal toxicity by assessing and measuring selected stress
biomarkers. Results were obtained by biochemical studies of tissues and sera after sacrificing the animal groups. Significant
increase levels of AST, ALT, ALP and creatinine were observed. Histopathological damage of the tissue's architecture and rise
in the liver and kidney MDA levels were also significant. In conclusion, the reversal effects of modulation of the biochemical
parameters and histological damage are attributed to the potential protective effects that ensued after administration of the
quercetin. However, further studies are warranted to facilitate that quercetin ameliorates the toxicity induced by Ec snake
venom in experimental animals.
abdulrahman.alasmari@gmail.com