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conferenceseries
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Volume 3
Diagnostic Pathology: Open Access
ISSN: 2476-2024
Laboratory Medicine 2018
June 25-26, 2018
June 25-26, 2018 | Berlin, Germany
13
th
International Conference on
Laboratory Medicine & Pathology
A comparison of paracetamol, ibuprofen or diclofenac potassium for pain relief following dental
extractions: A randomized controlled trial
Giath Gazal
Taibah University, Kingdom of Saudi Arabi
Objective:
To compare the effectiveness of different oral analgesics for relieving pain and distress in adults following the
extraction of teeth under local anaesthesia. The analgesics included paracetamol, ibuprofen and diclofenac potassium.
Methods:
This randomized controlled study was conducted from 10
th
of November 2015 until 10
th
of May 2016. 120 patients
were randomly allocated to one of three groups. Forty patients were in the paracetamol (1000 mg) group (control group), 40
in the ibuprofen (400 mg) group and 40 in the diclofenac potassium (50 mg) group. Evaluation of the post extraction pain
was made by patients immediately postoperatively, 2, 4 and 6 hours postoperatively on standard 100 mm visual analogue
scales (VAS), tagged at the endpoints with “no pain” (0 mm) and “unbearable pain” (100 mm). Furthermore, each patient was
observed preoperatively and immediately postoperatively for signs of distress by using a 5-point face scale.
Results:
There were significant decreases in mean pain scores for diclofenac potassium group compared to paracetamol and
ibuprofen groups at 4 and 6 hours postoperatively (P-values from one-way ANOVA: 0.00, 0.001, 0.04, 0.005). Changes in
distress scores from the preoperative score to the post-operative score were made using the paired sample t-test. There were
significant decreases in distress scores between the pre-operative and post-operative scores (P=0.001).
Conclusions:
This study has shown that diclofenac potassium was more effective than paracetamol or ibuprofen for
postoperative analgesia in adults who are having teeth extracted under local anaesthesia.
gazal73@yahoo.co.uk ggazal@taibahu.edu.saDiagn Pathol Open 2018, Volume 3
DOI: 10.4172/2476-2024-C1-003