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conferenceseries
.com
Volume 3
Diagnostic Pathology: Open Access
ISSN: 2476-2024
Laboratory Medicine 2018
June 25-26, 2018
June 25-26, 2018 | Berlin, Germany
13
th
International Conference on
Laboratory Medicine & Pathology
Vancomycin loaded super paramagnetic MnFe
2
O
4
nanoparticles coated with PEGylated chitosan to
enhance antibacterial activity
Akbar Esmaeili
and
Sepideh Ghobadian pour
Islamic Azad University, Iran
Background & Aim:
Increasing prevalence of antibiotic-resistant and failed-treatment make more investigations to deal
with these problems. Hence new therapeutic approaches for effective treatment are necessary. Ferrite superparamagnetic
nanoparticles have potential antibacterial activity.
Methodology:
In this study we prepared MnFe
2
O
4
superparamagnetic nanoparticles as core by precipitation method and used
chitosan crosslinked by glutaraldehyde as shell, then modified with PEG to increase stability of particles against RES.
Results:
Chitosan coating not only improves the properties of ferrite nanoparticles but also has antibacterial activity. FT-IR
confirmed this surface modification; XRD and SEM were developed to demonstrate particle size and characteristics of crystal
structure of these nanoparticles. Final particle size was reported approximately 25 nm. Magnetic properties of nanoparticles
were evaluated by VSM. Actual drug loading and releasing were examined by (UV-Vis) spectroscopy method.
Conclusions:
We employed liquid broth dilution method to assessment antibacterial activity of nanoparticles against
microorganisms. Significant antibacterial effect against gram negative bacteria was developed.
akbaresmaeili@yahoo.comDiagn Pathol Open 2018, Volume 3
DOI: 10.4172/2476-2024-C1-003