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conferenceseries
.com
Volume 3
Diagnostic Pathology: Open Access
ISSN: 2476-2024
Laboratory Medicine 2018
June 25-26, 2018
June 25-26, 2018 | Berlin, Germany
13
th
International Conference on
Laboratory Medicine & Pathology
The Periplasmic Chaperone Network of Campylobacter jejuni: Evidence that SalC (Cj1289) and
PpiD (Cj0694) Are Involved in Maintaining Outer Membrane Integrity
Shahid Ullah
Shenzhen University
A
lzheimer’s disease (AD) is considered as the most common type of dementia among older people. Almost 9 million
people are suffering from AD in China and increasing with the course of time. Currently many different herbs are used
for the treatment of AD including six flavors Rehmannia Pills, Gastrodia and Uncaria Drink. It has been suggested that some
acetyl-cholinesterase inhibitors induced molecular and cellular change that directly influence AD pathogeneses. In our study
literature search was performed to find mangrove ecosystem phytochemical structures by using Builder software implemented
in Molecular Operating Environment (MOE 2009). Acetyl-cholinesterase (PDB ID 1EVE) structure with bound ligand was
retrieved from Protein Data Bank. Molecular docking was performed by triangular matcher placement method and rescore
by London dG parameter. The crystal structure has bound ligand which was active against acetyl-cholinesterase. It can be
concluded by docking analysis of different compounds that mangrove ecosystem compound may serve as good inhibitors
against acetyl-cholinesterase.
Diagn Pathol Open 2018, Volume 3
DOI: 10.4172/2476-2024-C1-003