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Volume 3
Diagnostic Pathology: Open Access
ISSN: 2476-2024
Laboratory Medicine 2018
June 25-26, 2018
June 25-26, 2018 | Berlin, Germany
13
th
International Conference on
Laboratory Medicine & Pathology
Histopathological evaluation of carcinoma of breast in Modified Radical Mastectomy specimens
Pathak R, Jha A, Neupane PR, Chalise
and
S Basnyat AS
Nepal Medical College Teaching Hospital, Nepal
Background & Aim:
Carcinoma of breast has become the major public health problem among females in developing as well as
developed countries. In Nepal it comprises 6% of total cancers cases and often diagnosed at advanced stage. Surgical removal
or modified radical mastectomy (MRM) is the most commonly used tools for disease management. The aim of this study is to
identify the clinical, macroscopic and microscopic features of MRM specimens.
Materials & Methodology:
This prospective cross-sectional study was carried out in the Department of Pathology, Bhaktapur
Cancer Hospital, Bhaktapur, Nepal. Macroscopic and microscopic examination provided the tumor size, stage, grade, lymph
node status, lympho-vascular invasion and perineural invasion. Data were collected and analyzed using SPSS 16.
Results:
The study comprised 112 breast cancer patients of which 109 (97.3%) were females and 3 (2.7%) were males. Invasive
ductal carcinoma no specific type was the most common type of breast carcinoma. (84 cases) accounting 75% of total cases.
Carcinoma with medullary features was second most common (6 cases) comprising 5.4% cases followed by lobular, papillary,
apocrine, mucinious and NST mixed types. Grade II tumors were most frequent grade observed in 76.79% cases followed by
Grade I (12.50%) and Grade III (10.71%).
Conclusions:
As a conclusion invasive ductal carcinoma was the most common histological type breast cancer and the tumors
were found at T2 and N3 stage i.e maximum at grade II. Our study provides prognostic significance of histopathological
information in breast cancer management.
dr_rakesh@hotmail.comDiagn Pathol Open 2018, Volume 3
DOI: 10.4172/2476-2024-C1-003