central-nervous-system-2016_posters-accepted-abstracts

33 / 42

Notes:
Page 89
CNS 2016
December 05-07, 2016
Volume 7, Issue 5(Suppl) J Neurol Neurophysiol
ISSN: 2155-9562 JNN, an open access journal
conferenceseries .com
December 05-07, 2016 Dubai, UAE
2nd International Conference on
Central Nervous System Disorders & Therapeutics
Turhan Kandemir et al., J Neurol Neurophysiol 2016, 7:5(Suppl)
Interpretation of hippocampal MAP2/TAU levels in rats housed in different environments
Turhan Kandemir, Fulya Buge Ergen, Didem T Cosan and T Erhan Cosan
Eskişehir Osmangazi University, Turkey
Objective: Microtubules’ functions are important in neuronal development, plasticity and polarization. Disturbing changes
in microtubule organization and dynamics may cause loss of neuronal integrity and functions. Tau and other microtubule-
associated proteins (MAPs) promote the assembly and stabilization of neuronal microtubules. MAP2/Tau family proteins are
originally characterized by their ability to bind microtubules. MAP2 is found mostly in dendrites and tau is found mainly in
axons. Their bindings stabilize microtubules. Here, we discuss hippocampal MAP2/tau tissue levels in rats housed either in
enriched, standard and isolated environment.
Material & Method: The rats were kept in different environmental conditions (standard, rich and isolated). After one and
two weeks of the procedure, hippocampal microtubule-associated protein tau (MAPT) and microtubule-associated protein 2
(MAP2) levels were determined by enzyme-linked immunosorbent assay (ELISA) method.
Results: MAP2 levels in hippocampal region were periodically elevated during two weeks in the rats housed in enriched
environment. Tau protein levels were not apparently changed at first week in all groups, but were reduced at second week in
the rats housed in enriched environment.
Conclusion: In experimental studies on the investigation of MAP2/tau family, MAP2 and tau should be evaluated and
interpreted separately. Dendritic MAP2 may be elevated continuously in the enriched environment, but not axonal tau.
Biography
Turhan Kandemir is currently working as a Professor in the department of neurosurgery at Eskisehir Osmangazi University (Eskisehir, Turkey). He has published
several original research papers in reputed journals and also participated in several scientific meetings.