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CNS 2016
December 05-07, 2016
Volume 7, Issue 5(Suppl) J Neurol Neurophysiol
ISSN: 2155-9562 JNN, an open access journal
conferenceseries .com
December 05-07, 2016 Dubai, UAE
2nd International Conference on
Central Nervous System Disorders & Therapeutics
Didem T Cosan et al., J Neurol Neurophysiol 2016, 7:5(Suppl)
Hippocampal MAP2 levels reduce in the experimental sub-arachnoid hemorrhage: A preliminary
study
Didem T Cosan, Fulya Buge Ergen, Turhan Kandemir and T Erhan Cosan
Eskişehir Osmangazi University, Turkey
Objective: Subarachnoid hemorrhage is associated with severe morbidity and mortality. Disease may lead to impaired
consciousness and cognitive functions. Neuronal processing is supported by intracellular microtubule integrity and functions.
MAP2 interacting with microtubules leads to stabilization of microtubules, inhibition of depolymerization and increase in
microtubule rigidity.
Material & Method: We investigated hippocampal tissue microtubule-associated protein 2 (MAP2) levels in the rat groups
housing in isolated, standard or enriched environment, and results were obtained at 7th and 14th days after experimental
subarachnoid hemorrhage. The enzyme-linked immunosorbent assay (ELISA) method was used to measure the MAP2 levels
in rat’s hippocampal tissue samples. This assay was performed using commercially available ELISA kit.
Results: Hippocampal MAP2 levels were reduced in all groups at first and second week after subarachnoid hemorrhage.
Nevertheless, reducedMAP2 levels are more elevated in the rats housing in enriched environment compared with other groups.
Conclusion: In the progression of experimental subarachnoid hemorrhage, hippocampal MAP2 levels are being reduced
despite changing environmental status. Besides, the enriched environment in the subarachnoid hemorrhage may need further
investigations.
Biography
Didem T Cosan is currently working as an Assistant Professor in the Department of Medical Biology at Eskisehir Osmangazi University (Eskisehir, Turkey). He has
published several original research papers in reputed journals and also participated in several scientific meetings.