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Page 97
CNS 2016
December 05-07, 2016
Volume 7, Issue 5(Suppl) J Neurol Neurophysiol
ISSN: 2155-9562 JNN, an open access journal
conferenceseries .com
December 05-07, 2016 Dubai, UAE
2nd International Conference on
Central Nervous System Disorders & Therapeutics
J Neurol Neurophysiol 2016, 7:5(Suppl)
Cognitive impairment is correlated with and unstable mental health profile
Etindele Sosso Faustin Armel and Molotchnikoff Stéphane
University of Montreal, Canada
C erebral function is mainly reorganized during years between adolescence and midlife. This important period is
characterized by creation of synapses, fine-tuning of excitatory and inhibitory neurotransmitter systems, improvement
of brain structures, and development of nervous connections. Indeed most of brain diseases result due to variance or damage
to any of these events. Variances or imbalances in timing of neuronal maturity process strongly increase the risk for cognitive
impairments and certainly leads to the development of neurodegenerative diseases, dementia, anxiety and psychiatric disorders
in unknown rate in the groups of young adults (aged between eighteen years old until midlife). Moreover, these changes also
influenced the risk for Alzheimer disease, Dementia and other associated diseases. The aim of this study is to explore how
detection of cognitive impairments is link with a combined effect of sociodemographic items we choose, on a healthy young
adult’s population. This epidemiological study was leaded with a questionnaire incorporating the short fifteen items version of
cognitive complaints detection’s Mc Nair Test which is used for detect cognitive complains. The questionnaire also included ten
socio-demographic items and forty seven others questions divided in seven sections: quality of sleep, level of stress, depression,
anxiety, general health, physical skills, and dependences. Our results suggested a strong link between increasing in memory
deficit and the combination of at least two bad score to each section, with a significant correlation with unstable mental health
profile.
The effect of post-injury erythropoietin administration on mortality and Glasgow Outcome Scales
of patients with traumatic brain injury: A meta-analysis
Faye B Garciano
Makati Medical Center, Philippines
Aim: Aim of this study is to determine whether post-injury treatment with erythropoietin provides lower mortality rates and
improved Glasgow Outcome Scales in patients with traumatic brain injury (TBI).
Methods: Randomized controlled trials (RCTs) were searched through PubMed, Cochrane Central Register of Controlled
Trials (CENTRAL), MEDLINE and . The reference list of a systematic review was also searched.
Results: Four RCTs comparing erythropoietin and placebo, regardless of dose, dosing regimen, and route of administration
were reviewed. Data analysis showed that mortality rates for the erythropoietin group (OR 0.63, CI 0.43, 0.93) was significantly
lower compared to the placebo group. However, there was no significant difference in the Glasgow Outcome Scales of TBI
patients given erythropoietin compared to placebo.
Conclusion: Post-injury treatment with erythropoietin, regardless of dose, dosing regimen and route of administration yielded
lower mortality rates in patients with traumatic brain injury but had no significant effect on Glasgow Outcome Scales. It is
recommended that further large scale randomized controlled trials should be performed in order to fully establish the safety
and support the efficacy of erythropoietin administration in patients with traumatic brain injury.